Omega XL Review: Can This Supplement Really Support Your Joints?

Omega XL, with green-lipped mussel oil and omega fatty acids, aims to help with joint stiffness and muscle soreness using a natural, drug-free formula. Here’s a closer look at its potential benefits and limitations.
By Dermspotlight Staff |Updated Jan 8, 2026
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Key Takeaways

  • Omega XL uses a non-fish omega source derived from green-lipped mussels
  • The formula relies on a proprietary blend, limiting ingredient transparency
  • It is positioned as a premium joint support supplement
  • Results may vary depending on individual health status and expectations
  • Pricing is higher than standard fish oil supplements

Overview

Have you ever wondered how much your joints and muscles have to deal with daily? Your body is constantly under stress due to long working hours, everyday exercise, and aging. Over time, the strain may manifest itself as stiffness, soreness, or lack of mobility, and day-to-day chores may seem more difficult.

This is where joint support supplements usually find their way. One of the most talked about is Omega XL, which claims to use omega fatty acids obtained through green-lipped mussels rather than through fish oil. It is positioned as a drug-free, natural product, which promises to help in keeping joints comfortable and muscles healthy.

But to what extent is it effective? Let’s take a closer look.

What Is Omega XL?

Omega XL is a dietary supplement that comes in the form of a softgel that is meant to help promote the health of the joints and muscles. It uses green-lipped mussels, a native New Zealand shellfish, instead of fish oil as a source of omega fatty acids. It contains a proprietary extract called PCSO-524, as well as olive oil and vitamin E.

The supplement is marketed to those who have joint stiffness, less mobility or muscle pain due to age or exercise. Omega XL is formulated as a drug-free option for daily use and is usually taken as per the recommended dosage by the manufacturer. It is not meant to substitute medical care but to complement an active lifestyle.

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Omega XL Image/Dermspotlight

About The Brand

Omega XL is a wellness product made by Great HealthWorks, Inc, which is a U.S. based company with its headquarters in Fort Lauderdale, Florida. The company specializes in dietary supplements intended to promote joint health, mobility, and active living.

Great HealthWorks makes use of direct-to-consumer sales and has focused heavily on customer service, with phone and online support and satisfaction guarantees on a lot of its products. The brand claims to have a public face on third-party websites like the Better Business Bureau that assists in offering an extra layer of transparency to potential customers.

Fast Facts

Omega XL

Form Softgels
Benefit May support joint and muscle
Brand Great HealthWorks
Price Approximately $54.95
Number of Servings Per Container 30
Dosage 2 servings(4 softgels) daily for the first 8 weeks
Active Ingredients Green-lipped mussel oil extract (PCSO-524), Extra virgin olive oil, Vitamin E (d-alpha tocopherol)
Where to Buy Official Omega XL website or Amazon

Pros & Cons

Pros

  1. Uses green-lipped mussel oil instead of traditional fish oil
  2. Small, easy-to-swallow softgels
  3. No strong fishy aftertaste reported by many users
  4. Backed by a money-back guarantee

Cons

  1. Higher cost compared to standard omega-3 supplements
  2. A proprietary blend does not disclose individual ingredient dosages
  3. Effects may be mild or inconsistent for some users
  4. Not suitable for individuals with shellfish allergies
  5. The dosage serving is high

How Does It Work?

Omega XL is a supplement that works to provide the body with omega fatty acids that could aid in inflammatory regulation. Omega fatty acids are reputed to keep the joints lubricated, cells in good health and the inflammatory processes in check.

PCSO-524 is a lipid extract of the green-lipped mussels, which is the main distinguishing ingredient of Omega XL. It is a complex blend of fatty acids, which include the rare compounds of omega not usually found in fish oil. The manufacturer claims that these compounds may work in combination to help keep joints comfortable.

Olive oil and vitamin E are added to aid in the absorption of fats and give an antioxidant effect.

Ingredient Analysis

Green-Lipped Mussel Oil Extract (PCSO-524®)

PCSO-524 is a proprietary lipid extract from New Zealand green-lipped mussels, which is a complex of omega-3 fatty acids and other lipids.

Some clinical trials have demonstrated that PCSO-524 may be effective in relieving osteoarthritis pain and improving mobility as compared to normal fish oil, although results are inconsistent and further studies are required.

Olive Oil

Extra virgin olive oil provides monounsaturated fats such as oleic acid and antioxidants such as polyphenols.

According to a study published in Antioxidants (MDPI), such ingredients have the potential to decrease inflammation and oxidative stress and improve the health of the joints and the overall well-being, but there is limited direct evidence on supplements.

Vitamin E

Vitamin E (d-alpha tocopherol) is a lipid-soluble antioxidant that prevents the oxidation of fatty acids and could benefit overall health.

Research shows that it may have some effects on inflammatory biomarkers, but the clinical effects on joint-specific effects are not conclusive.

Benefits of Omega XL

  • Supports Joint Comfort: Omega XL claims to help keep the joints comfortable by supplying the body with the natural inflammatory balance of omega fatty acids, which may be helpful in stiffness associated with movement, aging, or exercise.
  • Promotes Mobility & Flexibility: Omega XL can help keep the joints lubricated and healthy, thereby preserving flexibility and ease of movement, which can be useful to people whose lifestyles are active or physically challenging.
  • Aids Muscle Recovery: The formula also states to assist muscle comfort after an exercise or a strenuous workout, possibly aiding in alleviating post-workout pain and muscle pain daily.
  • Easy to Use Daily: Omega XL is positioned as a hassle-free addition to any daily schedule. In small, softgel capsules, it aims to fit seamlessly into different lifestyles.

Potential Side Effects of Omega XL

Omega XL is made with natural ingredients, primarily green-lipped mussel oil, olive oil, and vitamin E, and is generally considered safe for most adults. However, some users may experience mild reactions:

  • Allergic Reactions: Individuals with shellfish allergies should avoid Omega XL, as the primary ingredient is green-lipped mussel extract.
  • Digestive Discomfort: Rarely, some people may notice mild stomach upset, nausea, or loose stools.
  • Mild Fatigue or Headache: On occasion, fatty acid supplements can trigger temporary fatigue or headache in sensitive individuals.

It’s always recommended to consult a healthcare provider before starting any new supplement, especially for pregnant or nursing women, people with chronic health conditions, or those taking other medications.

Dosage & Usage

Omega XL is in softgel form and is preferably taken with meals. The manufacturer advises taking four capsules a day during the initial eight weeks, but then it can be taken as a whole or divided into two in the morning and two in the evening.

Like any supplement, one is advised to seek medical advice before taking Omega XL- particularly pregnant and nursing women, people on medications, and those with chronic illnesses.

Pricing

One bottle of Omega XL containing 60 softgels costs about $54.95, and gives a 15-day supply at the advised doses of four softgels a day. This positions the product in the premium segment of joint support supplements.

Though it is convenient and has a proprietary formula, it might not be the most economical. Discounts tend to be average, and a few savings can be achieved on bulk purchases or subscription plans.

Customer Reviews

Customer feedback on Omega XL is mixed. Some users report noticeable improvements in joint comfort and reduced stiffness, while others feel little to no change even after consistent use. Many appreciate the small, easy-to-swallow softgels and the lack of a fishy aftertaste.

Sabrina says,

I’ve been taking Omega XL for a month, and my knees feel less stiff after daily walks. The softgels are easy to take, and I haven’t noticed any digestive issues.

Mark says,

I didn’t notice much difference after using Omega XL for six weeks. The softgels are convenient, but for the price, I expected better results.

Emily says,

Omega XL helped slightly with my joint soreness, but it’s not dramatic. I like that it’s natural and easy to take, yet the effects feel subtle compared to other options.

FAQs

Q: Is Omega XL better than fish oil?

A: Omega XL uses a different omega source than fish oil. Whether it is “better” depends on individual response and preference.

Q: Is Omega XL FDA-approved?

A: No dietary supplements are FDA-approved. Omega XL is manufactured under supplement regulations.

Q: Can Omega XL help with arthritis?

A: Some users report relief from joint discomfort, but results vary, and it should not replace medical treatment.

Q: Is Omega XL safe?

A: For most healthy adults, it is generally considered safe when used as directed. Those with shellfish allergies should avoid it.

Q: Does Omega XL help with heart health?

A: Omega fatty acids are associated with cardiovascular support, but Omega XL is marketed primarily for joint health.

Q: How long does it take to see results with Omega XL?

A: Some people notice mild changes within a few weeks, while others may need one to two months of regular use for noticeable joint support.

Q: Can Omega XL be taken with other supplements or medications?

A: It is often used with other supplements, but anyone taking medications should check with a healthcare professional first.

Q: Are there any age restrictions for using Omega XL?

A: Omega XL is made for adults. Younger users or those who are pregnant, nursing, or managing health conditions should seek medical advice before use.

Final Thoughts

Omega XL has a special combination of green-lipped mussel oil, providing a natural, drug-free solution to support joints and muscles. Its ease of use and the absence of fishy aftertaste are appreciated by the numerous users, although the outcomes are mixed.

The expectations should be realistic regarding the higher price, proprietary formula, and mixed effectiveness. Whether Omega XL will fit into your routine is based on your health objectives, budget, and lifestyle.

For those uncertain, consulting a healthcare professional can provide guidance and help determine if it complements your existing joint health strategy.

Lana Pinchasov, PA-C

By Lana Pinchasov, PA-C

Lana Pinchasov, PA-C is a nationally certified dermatology physician assistant licensed in New York.

3 sources

[1] Perna canaliculus Lipid Complex PCSO-524™ Demonstrated Pain Relief for Osteoarthritis Patients Benchmarked against Fish Oil, a Randomized Trial, without Placebo Control https://www.mdpi.com/1660-3397/11/6/1920
[2] Extra Virgin Olive Oil Polyphenol-Enriched Extracts Exert Antioxidant and Anti-Inflammatory Effects on Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients https://www.mdpi.com/2076-3921/14/2/171
[3] Vitamin E - Health Professional Fact Sheet https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/

**This is a subjective assessment based on the strength of the available information and our estimation of efficacy.

*Result may vary. The information contained in this website is provided for general informational purposes only. No medical claims are implied in this content, and the information herein is not intended be used for self diagnosis or self treatment of any condition.

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