What Are Stem Cell Serums?

Stem cell serums are multi-beneficial skincare anti-aging formulas which can promote skin cell renewal, repair damage to the skin barrier, heal wounds, and promote collagen and elastin production. This can tighten your complexion, improve elasticity, and smooth any existing wrinkles and lines on your skin.

Besides being high in collagen producing peptides, stem cells also contain amino acids which are largely responsible for the rejuvenating skin benefits, and antioxidants which repair the skin barrier and protect your complexion UV rays and other environmental threats.

According to board certified dermatologist Michele Green, “These are the building blocks for cell rejuvenation, so over the past few years, there have been a variety of both animal-and plant-based stem cells in skin care products [1].”

In this article, we’ll tell you everything you ever wanted to know about stem cell serums, and offer our list of the best stem cell serums on the market today as evaluated and rated by our team of board-certified dermatologists.

Best Stem Cell Serums

Our Top Picks For Best Stem Cell Serums

Most Popular Stem Cell Serum Beverly Hills MD Age Delay Stem Cell Serum
Best Anti-aging Stem Cell Serum Bioeffect EGF Serum
Best For Wrinkle Juice Beauty Stem Cellular Anti-Wrinkle Booster Serum
Top Stem Cell Skin care Products Introstem Stem Cell Anti-Aging Wrinkle Treatment Syringe
Best Stem Cell Serum for Face Ronas Stem Cell Solution
Best Stem Cell Serum Indie Lee Stem Cell Serum
Best Stem Cells Skin Care Products Swiss Apple Stem Cell
Best Botanical Stem Cell Serum Hydropeptide Hydrostem +6
Best Skin Illuminating Serum ReLuma Skin Illuminating Anti-aging Serum
Best Advanced Growth Factor Serum Osmosis StemFactor Serum
Best Stem Cell Therapy Serum Venus Skin Stem Cell Therapy Serum

It’s important to note that not every stem cell serum will work for everyone, and your results may vary.

Best Stem Cell Serums

Beverly Hills MD Age Delay Stem Cell Serum

Beverly Hills MD Age Delay Stem Cell Serum

Beverly Hills MD Age Delay Stem Cell Serum is an anti-aging serum that revitalizes the power of stem cells. It supports active cell renewal making your skin more healthy and remarkably youthful at any age. Age Delay Stem Cell Serum uses an advanced combination of ingredients that promotes a more youthful-looking complexion.

The Reviewers Say:

I’ve used this serum for a few months and noticed my fine lines becoming less noticeable. The formula is lightweight, absorbs quickly, and is fragrance-free. Overall, a great investment for improving skin texture and tone. ~ Shellie

Key Facts

Container Type: Pump Bottle | Features: Repairing, Smoothing, Glowing | Skin Type: For All Skin Types | Size: 1 fl oz (30 ml) | Form: Serum | Brand: Beverly Hills MD


Bioeffect EGF Serum

Bioeffect EGF Serum is an anti-aging growth factor serum that contains EGF, a protein that stimulates cell renewal and growth, improves skin texture and tone, and reduces the appearance of wrinkles and fine lines. According to the manufacturer, its skincare formula contains only 7 ingredients for maximum efficacy. It is formulated to be lightweight and fast-absorbing and can be used daily as part of a skincare routine.

The Reviewers Say:

The BioEffect EGF Serum is fantastic! My skin is normal to oily, with hormonal breakouts around my jawline. This serum has helped to control my breakouts and does not clog my pores. My skin is clear and radiant. ~ Tracie B

Key Facts

Container Type: Bottle | Features: Boosts Hydration and Moisture Retention | Skin Type: For All Skin Types | Size: 0.5 fl oz (15 ml) | Form: Serum | Brand: BioEffect


Juice Beauty Stem Cellular Anti-Wrinkle Booster Serum

Stem Cellular Anti-wrinkle booster aims to reduce the appearance of wrinkles. This serum contains a blend of organic fruit stem cells and Vitamin C, which helps to improve the skin’s texture and firmness. The formula also includes resveratrol, a powerful antioxidant found in red wine, which can help protect the skin from environmental damage.

The Reviewers Say:

I am pretty sure by my booster serum and use it every day and night!! I’ve been using Juice Beauty’s stem cellular line for a year and my skin has looked better. ~ Justyna V

Key Facts

Container Type: Bottle | Features: Improved Skin Texture | Skin Type: For All Skin Types | Size: 1 fl oz (30 ml) | Form: Serum | Brand: Juice Beauty


Introstem Stem Cell Anti-Aging Wrinkle Treatment Syringe

Introstem Stem Cell Anti-Aging Wrinkle Treatment Syringe
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View On AmazonPrice: $75.44

Introstem Stem Cell Serum is a skincare product that is designed to reduce the appearance of wrinkles and fine lines using stem cells. It contains a blend of plant-based stem cells, including Swiss apple stem cells and argan stem cells, which have anti-aging properties. This stem cell treatment comes in a syringe-like applicator, which helps deliver the product precisely to the targeted areas.

The Reviewers Say:

I’ve had it for three months and I’m already seeing results! I can’t believe the difference; I would recommend it to anyone who is annoyed by lines or puffiness. ~ Chris

Key Facts

Container Type: Syringe | Features: Anti-Aging | Skin Type: For All Skin Types | Size: 15 fl oz | Form: Serum | Brand: Introstem


Ronas Stem Cell Solution

Ronas Stem Cell Solution
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View On AmazonPrice: $65.00

This professional-grade Ronas Stem Cell solution revitalizes the skin and restores bright, crystal-clear skin tone and elastic skin with the help of its soothing effect. Its multi-layer liposome formula penetrates deeply to soften rough, dry skin. The formula is free from parabens, sulfates, and artificial fragrances, which makes it the best stem cell serum for face. You could also look for the Ronas Stem Cell Solution review to know further about it.

The Reviewers Say:

Yes, I love it, my face is pretty bright restored with no sun spots, no acne. It brightens and gives a youthful skin texture too. ~ Tammy

Key Facts

Container Type: Bttle | Features: Revitalizing, Moisturizing, Soothing Skin | Skin Type: For All Skin Types | Size: 5 ml x 10 Vials | Form: Serum | Brand: Ronas


Indie Lee Stem Cell Serum

Indie Lee Stem Cell Serum
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View On AmazonPrice: $33.00

Indie Lee Stem Cell Serum is a potent serum that is formulated to help improve the appearance of fine lines, wrinkles, and uneven skin tone. The key ingredient in the Indie Lee Stem Cell Serum includes Alpine Rose which is known for its anti-oxidant properties; Echinacea Stem Cells, which help improve the appearance of firmer skin.

The Reviewers Say:

Supports the healing of my new blemishes and the resurfacing of skin with old acne scars. There is no sticky residue or strong scent, making it suitable for sensitive skin. Cristina C.

Key Facts

Container Type: Bottle | Features: Antioxidants, Softens Skin | Skin Type: For All Skin Types | Size: 1 fl oz (30ml) | Form: Serum | Brand: Indie Lee


Swiss Apple Stem Cell

This stem cell serum is designed to help with skin tone, discoloration, and smoothing the natural fine lines and wrinkles that come with aging skin. The plant-derived stem cells used in this serum result in plumper-looking skin, which helps to counteract decreasing elasticity for a more youthful appearance. It’s the best apple stem cell serum.

The Reviewers Say:

A fantastic product. Many other serums had failed to work for my skin, but this one has been fantastic. Pamela

Key Facts

Container Type: Bottle | Features: Elasticity, Discoloration, Youthful Appearance | Skin Type: For All Skin Types | Size: 1 fl oz (30ml) | Form: Serum | Brand: Swiss Botany


Hydropeptide Hydrostem +6

HydroStem is a daytime skin serum designed to protect and strengthen your skin using a nourishing blend of botanical stem cells. Packed with antioxidants and a Perfection Peptide, an epigenetic ingredient, it shields your skin from various environmental stressors. This hydrating serum deeply revitalizes your skin, enhancing its radiance visibly.

The Reviewers Say:

Such an awesome serum. I use it every morning (spiked with firma-bright vitamin c) and love knowing that my skin is protected against sun / blue light. also has worked wonders if i use it at night after too many hours in the sun! ~Terry

Key Facts

Container Type: Pump Bottle | Features: Anti-Aging | Skin Type: For All Skin Types | Size: 1 fl oz (30 ml) | Form: Serum | Brand: HydroPeptide


ReLuma Skin Illuminating Anti-aging Serum

ReLuma Skin Illuminating Anti-aging Serum
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View On AmazonPrice: $145.00

Reluma Skin Illuminating Serum contains matrix proteins derived from Stem Cell Core Technology. With a high concentration of Polypeptide Enriched Media (P.E.M), this serum enhances the look of your skin and supports overall skin vitality. The advanced formula rejuvenates your appearance, helping you achieve a more beautiful and revitalized look and feel.

The Reviewers Say:

I have used this product for several years. I feel it makes my face smoother and gives me a more youthful look. I recommend this product. ~ Geebs

Key Facts

Container Type: Pump Bottle | Features: Hydrating, Anti-aging | Skin Type: For All Skin Types | Size: 0.5 fl oz (15 ml) | Form: Serum | Brand: ReLuma


Osmosis StemFactor Serum

Osmosis StemFactor Serum
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View On WalmartPrice: $67.20

Osmosis Growth Factor Serum is an advanced serum designed to replenish the skin’s growth factors and proteins using patented methods. It supports stem cells and fibroblasts, aiding the skin’s repair process and promoting the development of new cells. This helps address various aspects of aging and damage, contributing to more youthful-looking skin.

The Reviewers Say:

My esthetician recommended that I replace what I was using with Growth Factor Serum and she was right. Three months later and I’m here buying two more. One for myself and one for my sister. My skin looks younger and smoother. ~ Isabel

Key Facts

Container Type: Pump Bottle | Features: Anti-aging | Skin Type: For All Skin Types | Size: 1 fl oz (30 ml) | Form: Serum | Brand: Osmosis


Venus Skin Stem Cell Therapy Serum

The Venus Skin™ SCT Serum is made to work with the Venus Skin™ SCT Accelerator, creating a skin care duo known as the [Power + Duo]. This serum has growth factors from stem cells, strong antioxidants, and other active ingredients. Its goal is to help the skin heal, lessening the look of fine lines, wrinkles, redness, and discoloration. The formula gets quickly absorbed, so it starts working right away.

The Reviewers Say:

Venus Skin Stem Cell Therapy Serum provides decent hydration without feeling greasy. While it’s gentle on the skin and has a mild fragrance, I haven’t seen remarkable changes in fine lines. There’s a subtle improvement in skin tone, but the higher price point might not justify the results for everyone. It’s a reasonable addition to a routine, but not a standout product in my experience. ~ Heloisa

Key Facts

Container Type: Pump Bottle | Features: Anti-aging | Skin Type: For All Skin Types | Size: 1 fl oz (30 ml) | Form: Serum | Brand: Venus


What Are the Pros and Cons?

Pros

  1. Stem cell serums can reduce wrinkles and fine lines.
  2. They can promote cell turnover for fresher, more youthful looking skin.
  3. Stem cell serums can tighten the complexion and improve elasticity.
  4. These formulas can repair damage to the skin barrier.
  5. Stem cell products can make the skin soft and supple.

Cons

  1. The results may vary for different individuals.
  2. Some products come in small bottles, so you may have to reorder every 2 months.
  3. The most popular brands could run low stock at times.

How Did We Evaluate Stem Cell Serums?

In order to decide on the best stem cell face serum products, our team of board certified dermatologists ranked dozens of formulas according to a set of criteria. These are some of the primary factors they looked at, and these are the same features you should consider if you research brands on your own:

Reputability of the Manufacturer

When purchasing any skincare product including stem cell formulas, we find that it’s usually best to buy from a highly reputable manufacturer known for producing quality, safe, products. There may be some smaller or little known companies that make great skincare as well, so this is just a rule of thumb.

Ingredients

Look for a serum that contains organically sourced ingredients with no artificial or chemical additives or fragrance that could be irritating to the skin. All of the best stem cell skin care products our experts chose are natural, and the ingredients have scientific studies to support their efficacy.

Value For Cost

The prices of stem cell serums differ quite widely depending on the brand, so naturally you should choose a product that suits your budget. However, weigh the stem cell serum benefits against the cost to see if the product is worth it. Our team chose best stem cell serums that are high value for the price.

Return Policy/Guarantee

The return policy or guarantee that a company offers says a lot about the confidence they have in the quality and efficacy of their products. In general, our team gave high points to manufacturers that give at least a 30-60 day return policy so you have sufficient time to try the item out to see if it works well for you.

Safety

Our team looked for brands that the company manufactures and tests in an FDA-registered facility according to GMP safety standards, and this is a factor you should certainly look for.

Customer Reviews

Reading through the stem cell serum reviews is a great way for you to learn about the advantages and disadvantages of the product, and other pertinent details about the customer experience. Our team only recommended products that got high ratings and positive feedback from users.

How Do Stem Cell Serums Work?

Stem cell serums stimulate new cell production, promoting renewed and rejuvenated skin, revitalizing a dull complexion and making it more youthful-looking, and helping to unclog the pores and decrease acne breakouts.

An article published in Anais Brasileiros de Dermatologia by Karolyn Sassi OgliariDaniel MarinowicDario Eduardo Brum, and Fabrizio Loth explored the role of stem cells in dermatology [4].

Most products boost collagen and elastin release, making the skin tighter, enhancing elasticity, and decreasing the depth and appearance of wrinkles and fine lines.

A study on female volunteers published in the Journal of Cosmetics, Dermatological Sciences and Applications by Rachel Lubart and Anat Lipovsky concluded that application of topical collagen regularly improved firmness and elasticity and smoothed wrinkles and lines [5]

The majority of stem cell serums contain some ingredients which moisturize the complexion, get rid of dryness, and plump the skin to further smooth signs of age like fine lines, as we explained in our article about the best face oils.

A study on skin moisturizers published in the Journal of the American Academy of Dermatology concluded that they have therapeutic potential in the maintenance and prevention of dry skin [6]

In addition, facial serums are high in anti-inflammatory agents which can lessen swelling and help heal skin conditions like eczema. These best human stem cell skin care products are also rich in free radical-abolishing antioxidants which lower oxidative stress levels.

This results in repair and healing of the skin barrier, a boost in skin immunity, and protection from environmental agents like UV rays and pollution.

What Are Some of the Ingredients To Look For?

These are some of the key ingredients you should look for in the best stem cell serums:

Malus Domestica Apple Stem Cell Extract

This is a liposomal blend of stem cells extracted from a rare Swiss apple. They promote skin renewal and repair, boost rejuvenation, and extend skin cell longevity. They may also decrease wrinkles and fine lines, and repair damage to the skin tissue.

An in-vivo study published in Advances in Materials Science and Engineering by Danial Khayatan, et al concluded that Malus Domestica apple stem cell extract was effective at healing skin damage and reducing inflammation [4].

Apocynin

Apocynin is an organic compound which has the ability to boost collagen levels significantly, for tighter, more elastic skin with less prominent wrinkles and fine lines. It also enhances the health and vibrance of the complexion.

A study published in the European Journal of Histochemistry confirmed that apocynin stimulates collagen synthesis for anti-aging benefits and skin rejuvenation [5].

In addition, it has potent antioxidants which repair skin barrier damage and anti-inflammatory agents which soothe and heal.

Resveratrol

This is a bioactive agent rich in polyphenols, found primarily in red grapes. Its high antioxidant levels promote skin barrier healing and protect from UV rays. Resveratrol increases the synthesis of collagen, which firms the skin and smooths wrinkles and fine lines.

In addition, it may reduce dark spots and area of hyperpigmentation on the skin, and resveratrol also decreases inflammation.

A review of the literature published in the Advances in Dermatology and Allergology by Kamil Leis, et al concluded that resveratrol has anti-aging benefits and is an excellent ingredient for dermatology and cosmetology products [6].

Jojoba Oil

The oil from the Simmondsia Chinensis plant is deeply hydrating, making it an ideal moisturizer which eliminates dry, flaky skin and plumps to smooth wrinkles and lines.

It may also boost collagen levels, for tighter skin and a further reduction in lines. Jojoba has potent anti-inflammatory agents and antioxidants which help heal skin conditions, decrease redness and swelling, and repair damage to the skin barrier.

A review published in Anais Brasileiros de Dermatologia by N Pazyar and R Yaghoobi, et al explored the research on the role of jojoba in dermatology [7].

How Do You Use Stem Cell Serums?

The instructions will vary for the individual product, but normally you should use a stem cell serum 2-3 times a week as part of your skincare routine, before applying your moisturizer.

However, some formulas you can use on a daily basis, depending on the product. Follow the specific directions on the label.

In general, apply the serum evenly all over your face, either with your hands or with the dropper or applicator if provided.

FAQs

Q: Do Stem Cell Serums Work?

A: The best stem cell face serum products like the ones we have recommended in this review should work well. Look for some of the ingredients we have discussed, or others that have research supporting their benefits. These formulas should effectively promote cell renewal and rejuvenation and offer anti-aging benefits.

Q: How Often Do You Use Stem Cell Serum?

A: Some dermatologists recommend that you only use stem cell serums 2-3 times a week, and others say you can use them daily. To some extent it depends on the formula, so follow the directions for the product you buy.

Q: What Are the Side Effects of Stem Cell Serum?

A: Whether the particular serum you buy causes skin irritation depends on the ingredients. All of the products we have recommended should be side effect free, unless you have a specific allergy. Make sure to choose a formula without sulfates, parabens, and other artificial or chemical additives.

Q: Are Stem Cell Serums Suitable for All Skin Types?

A: Yes, stem cell serums are formulated to be suitable for various skin types, including oily, dry, sensitive, and combination skin. However, individual reactions may vary, so it’s advisable to perform a patch test.

Q: Can I Combine Stem Cell Serums With Other Skincare Products?

A: Yes, stem cell serums can be combined with other skincare products. However, it’s essential to follow a consistent routine and introduce new products gradually to monitor skin reactions.

Q: Are Stem Cell Serums Worth It?

A: Whether a particular serum is worth it or not depends on the quality of the product, its ingredients, the price, and other features we have mentioned. Do your research carefully. Certainly, our team of dermatologists feels that all of the recommended brands are worth it.

Q: How Much Do Stem Cell Serums Cost, and Where Can I Buy Them?

A: There are a wealth of options on the market, so you can find stem cell serums for sale on many online websites as well as in cosmetics stores, pharmacies, and from other shops.

If you want a specific brand, look to their official website for purchasing details. The prices vary widely depending on the brand, size of the product, and other factors.

Quick Comparison Table

Product Rating Best For Key Ingredients Return Policy
Beverly Hills MD Age Delay Stem Cell SerumBeverly Hills MD Age Delay Stem Cell SerumPrice. $110Size. 1.7 Oz Rating Best for Repairing, Smoothing, Glowing Glycerin, Capric Triglyceride, Palmitoyl Tripeptide-3 30-Days
Bioeffect EGF SerumBioeffect EGF SerumPrice. $159.99Size. 0.34 fl Oz Rating Visibly Smoother, Plumper, and Firmer Skin Barley EGF, Hyaluronic Acid, Glycerin, Icelandic Water 30-Days
Juice Beauty Stem Cellular Anti-Wrinkle Booster SerumJuice Beauty Stem Cellular Anti-Wrinkle Booster SerumPrice. $72.00Size. 15 ml Rating Replenish, Restore & Renew Skin Resveratrol, Grape Juice, Jojoba Oil, Shea Butter 30-Days
Introstem Stem Cell Anti-Aging Wrinkle Treatment SyringeIntrostem Stem Cell Anti-Aging Wrinkle Treatment SyringePrice. $75.44 Size. 15 ml Rating Anti-Aging Aqua, Sodium Silicate, Magnesium Aluminum Silicate 30-Days

Conclusion

Stem cell serums promote cell renewal and rejuvenation, giving you a fresher, more vibrant complexion. Most contain collagen-boosting ingredients like peptides which help tighten your skin and smooth fine lines and wrinkles. These antioxidant-rich formulas also repair damage to the skin barrier and protect from UV rays and other environmental agents.

All of the products our dermatologists have recommended in this article are among the best stem cell serums on the market today, and the suggested formulas also got primarily glowing reviews from customers who were happy with the stem cell serum benefits. There was no mention of irritation or other side effects with any of these selections.

We’re certain that you’ll be able to find the best stem cell serum for face that suit you from among the choices we have recommended, and you also have the information to help you research brands on your own. If you want to have a look at additional anti-aging skincare products, read our article about the best face serums on the market. Good luck!

Dr. Mary Beth Parisi, MD

By Dr. Mary Beth Parisi, MD

Dr. MaryBeth Parisi is a board-certified Harvard trained Dermatologist. She has over 18 years of experience in the field of skin care.

13 sources

[1] Stem Cells in Skin Care: What They Do and How They Work: https://www.dermstore.com/blog/stem-cells-in-skin-care/
[2] Stem Cells In Dermatology: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008060/
[3] Immediate and Long Term Clinical Benefits of a Novel Topical Micronized Collagen Face Cream: https://www.scirp.org/journal/paperinformation.aspx?paperid=121643
[4] Skin Moisturizers: Therapeutic Potential And Preventative Maintenance Of Dry Skin: https://www.jaad.org/article/S0190-9622(07)01815-4/fulltext
[5] https://www.researchgate.net/publication/359350639_Effect_of_Apple_Malus_Domestica_Stem_Cells_on_UVB-Induced_Damage_Skin_with_Anti-Inflammatory_Properties_An_In_Vivo_Study
[6] Apigenin Induces Dermal Collagen Synthesis Via smad2/3 Signaling Pathway: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503966/
[7] Resveratrol As A Factor Preventing Skin Aging And Affecting Its Regeneration: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326919/
[8] Jojoba In Dermatology: A Succinct Review: https://pubmed.ncbi.nlm.nih.gov/24442052/
[9] Current Advanced Therapies Based on Human Mesenchymal Stem Cells for Skin Diseases: https://www.frontiersin.org/articles/10.3389/fcell.2021.643125/full
[10] Stem Cell Therapy On Skin: Mechanisms, Recent Advances And Drug Reviewing Issues: https://www.sciencedirect.com/science/article/pii/S1021949817301874
[11] The Fountain of Stem Cell-Based Youth? Online Portrayals of Anti-Aging Stem Cell Technologies https://academic.oup.com/asj/article/35/6/730/2589147?login=false
[12] Application of Plant Stem Cells in Cosmetics: https://www.walshmedicalmedia.com/open-access/application-of-plant-stem-cells-in-cosmetics-112565.html
[13] Stem Cell Technology and the Skin: https://www.hmpgloballearningnetwork.com/site/thederm/site/cathlab/event/stem-cell-technology-and-skin