What Are Anti-Aging Supplements?

As we age, levels of collagen, elastin, and hyaluronic acid in the skin decline, which may make the skin looser, drier, and more prone to developing wrinkles and lines.

Anti-aging supplements are capsules which aim to boost skin health, increase collagen, elastin, and hyaluronic acid, fade dark spots, and eliminate wrinkles and fine lines on the complexion.

Registered dietitian Maya Feller of Maya Feller Nutrition explains:

“Aging is a result of normal biological functioning where there are marked changes in our cells. The process of aging can be accelerated secondary to diseases. We know that antioxidants from foods and some supplements may act in a protective manner, reducing cellular damage [1].”

In this article, we’ll give you all of the information you need to understand how anti-aging supplements and vitamins work and how to choose the best one for you. We’ll also tell you about the best supplements for skin aging in this category, as evaluated by our team of board-certified dermatologists.

Expert’s Advice on Anti-Aging Supplements and Vitamins

  • Dr. Richard Foxx is the founder and Medical Director of FoxxMD Evolutionary Skin Care in California. He is certified by the National Board of Medical Examiners and is a member of the American Academy of Anti-aging MedicineDr. Foxx recommends 10 essential nutrients and supplements for better aging, including protein, multivitamins, CoQ10, resveratrol, omega-3 fatty acids, vitamin D, magnesium, probiotics, collagen, and nicotinamide riboside.

What Are the Benefits?

  • Anti-aging supplements can tighten the skin and improve elasticity.
  • They can smooth wrinkles and fine lines.
  • These supplements boost skin hydration and eliminate dryness.
  • Anti-aging capsules can repair damage to the skin barrier.
  • They can reduce inflammation and heal skin conditions.

Why Trust Dermspotlight?

As the leading source for dermatologist-recommended skincare, beauty, and wellness products, especially with the best anti aging products and supplements, you can trust Dermspotlight to provide honest and reliable reviews of the best anti aging supplements 2024. Our team of writers carefully evaluates each supplement based on ingredients, effectiveness, and real customer reviews.

We understand how important it is to find an anti-aging supplements and vitamins that really works, which is why we take the time to thoroughly research and test top products. In addition to our supplement reviews, Dermspotlight offers valuable guides reviewed by dermatologists. You can learn more about your skin and which supplement characteristics may work best for you.

It is difficult to find this level of expertise or dedication to quality anywhere else. When searching for the right anti-aging supplements, you need a source you can trust. As the leader in dermatologist-recommended skincare, Dermspotlight has your best interests in mind. Read our best anti aging supplements reviews with confidence to discover the most effective anti-aging supplements.

Best Anti-Aging Supplements and Vitamins

Our Top Picks For Best Anti-Aging Supplements and Vitamins

Best Supplement for Anti aging Beverly Hills MD Dermal Repair Complex
Best Organic Anti-aging Skin Supplement ActivatedYou Essential Skin Food
Best Anti Aging Vitamin supplements Nature’s Bounty Vitamin C
Best Anti-ageing Pills ResveraCel by Thorne
Best Selenium Anti Aging Supplement Pure Encapsulations Selenium
Best Age Reversing Supplements Life Extension Optimized Saffron
Best Vitamins for Skin Aging Nordic Naturals Vitamin E Complex
Best Supplement For Skin Health Tru Niagen

Best Anti-Aging Supplements and Vitamins

Discover the secret to youthful radiance with our top-rated anti ageing supplements and vitamins. Rejuvenate your skin and boost overall wellness.

Beverly Hills MD Dermal Repair Complex

Beverly Hills MD Dermal Repair Complex is an all-natural anti-aging supplement that addresses common signs of aging such as wrinkles, fine lines, dryness, and uneven skin tone. This supplement for anti-aging is formulated with scientifically backed ingredients that help improve skin elasticity giving you a youthful and beautiful appearance.

The Reviewers Say:

I’ve been using dermal repair for a long time. My skin appears more radiant and smooth. People have told me that I to seem ten years younger than I am because of this aging supplement. I am 59. ~Brandy

Key Facts

Container Type: Jar | Features: Tightening & Smoothing effect | Size: 60 Count | Form: Capsules | Dosage: 2 Capsules Daily |Brand: Beverly Hills MD

ActivatedYou Essential Skin Food

This supplement for aging skin is designed to improve the appearance of skin that looks and feels tight, smooth, and youthful at any age. Essential Skin Food claims to reduce fine lines and wrinkles, promote cell turnover, and fight skin-damaging free radicals to promote healthy skin.

The Reviewers Say:

I am in my early 50’s and receive compliments on my skin. That is due to a healthy diet and the Essential Skin Food supplement. Thank you for providing this youthful supplement, ActivatedYou. ~Adriana F

Key Facts

Container Type: Jar | Features: Smooth, Tight, and Youthful Skin | Size: 30 Count | Form: Capsules | Dosage: 1 Capsule Daily | Brand: ActivatedYou

Nature’s Bounty Vitamin C

Nature’s Bounty Vitamin C

View On WalmartPrice: $7.59

This anti-aging vitamins formula contains vitamin C, an essential nutrient and powerful antioxidant in many processes in the body such as immune function and collagen synthesis. Vitamin C offers anti-aging benefits that help protect the skin from damage caused by free radicals which can be a reason for premature aging.

The Reviewers Say:

I’ve been taking Nature’s Bounty Vitamin C for a few months and my skin looks brighter and smoother. I appreciate the high dose of vitamin C in an easy-to-take tablet form. I recommend this vitamin supplement to anyone looking for an effective and affordable anti-aging supplement. ~Louise

Key Facts

Container Type: Bottle | Features: Immune Support, Anti-Aging | Size: 100 Count | Form: Tablet | Dosage: One Tablet Daily | Brand: Nature’s Bounty

ResveraCel by Thorne

ResveraCel by Thorne

View On WalmartPrice: $54

ResveraCel is an anti-aging supplement that promotes NAD+ production, cellular repair, and cellular energy production, thereby promoting healthy aging. It contains a blend of nutrients, including nicotinamide riboside, trans-resveratrol, quercetin, and betaine. These ingredients work together to support overall health.

The Reviewers Say:

I take two in the morning and have noticed a significant increase in my energy levels throughout the day. ~David F

Key Facts

Container Type: Bottle | Features: Anti-aging, Energy | Size: 60 Count | Form: Capsules | Dosage: 2 Capsules Daily | Brand: Thorne Research

Pure Encapsulations Selenium

Pure Encapsulations Selenium

View On WalmartPrice: $33.40

This anti-aging supplement helps protect normal cell function and supports the immune system. Pure Encapsulations Selenium contains 200 mcg of selenium per capsule and it is designed to assist with overall health and well-being. It protects your cells from oxidation and because of its antioxidant activity, it has anti-aging properties.

The Reviewers Say:

I have full trust in all of Pure Encapsulations products. I’ve been taking their selenium for over a year and it’s greatly improved my overall health.~Clee

Key Facts

Container Type: Bottle | Features: Antioxidant Defense, Cellular Health | Size: 180 Count | Form: Capsules | Dosage: 1 Capsule Daily | Brand: Pure Encapsulations

Life Extension Optimized Saffron

Life Extension Optimized Saffron

View On WalmartPrice: $18.75

Life Extension Optimized Saffron supplement is marketed as an anti-aging supplement due to its ability to support a healthy mood and reduce stress-related eating behaviors. The other potential benefits of this anti-aging supplement include support for cardiovascular health, cognitive function, and vision health.

The Reviewers Say:

This is effective! I am grateful for this supplement because it has improved my mood without making me numb. It also promotes restful sleep and prevents overeating! ~David

Key Facts

Container Type: Bottle | Features: Boost Energy | Size: 60 Count | Form: Capsules | Dosage: (1) Capsule Twice Daily | Brand: Life Extension

Nordic Naturals Vitamin E Complex

Nordic Naturals Vitamin E Complex

View On WalmartPrice: $17.81

Nordic Naturals Vitamin E Complex is a dietary supplement that contains six different forms of vitamin E for antioxidant support. It protects the body from oxidative stress, which contributes significantly to the process of aging. Furthermore, Vitamin E may support the decrease of fine lines and wrinkles, the improvement of skin texture, and the protection of the skin from UV damage.

The Reviewers Say:

I’ve been taking Nordic Naturals Vitamin E Complex for a few months and my skin feels smoother and more hydrated. I’ve noticed a reduction in the appearance of fine lines around my eyes. I appreciate the high-quality ingredients and sustainable practices of Nordic Naturals. I recommend this vitamin supplement for anyone looking for an effective anti-aging supplement. ~Walter

Key Facts

Container Type: Jar | Features: Antioxidant | Size: 30 Count | Form: Softgel | Dosage: Twice Daily | Brand: Nordic Naturals

Tru Niagen NAD+

Tru Niagen NAD+

View On WalmartPrice: $47.30

For its ability to support cellular health and function by increasing NAD+ levels, Tru Niagen is promoted as an anti-aging supplement. It also claims to improve heart health and slow the onset of aging symptoms by increasing the body’s level of a substance known as NAD+.

The Reviewers Say:

Its immediate effects are noticeable within a few days. I’m feeling a lot better and have a lot more energy after using this anti aging supplement. ~Carol C

Key Facts

Container Type: Bottle | Features: Energy Management, Stress Relief | Size: 30 Count | Form: Capsules | Dosage: One Capsule Daily | Brand: Tru Niagen

How Did We Evaluate Anti-Aging Supplements?

In order to come up with our list of the best anti-aging supplements on the market, our team of dermatologists looked at many, many products and ranked each according to a set of criteria.

Here are some of the most important features our experts considered to come up with the best anti-aging supplements 2024, and you should use the same list yourself when researching brands.

The Manufacturer Has a Good Reputation

Some of the smaller, less well-known companies may offer quality products, but in general its usually best to go with a highly reputable, well-liked brand that has built a good reputation. Our team give higher points to companies known to offer safe, quality health and skincare products.

The Ingredients and Benefits Are Supported By Scientific Evidence

The team looked for formulas with ingredients that are as purely organic as possible, and free of artificial or chemical additives. In addition, we selected anti-aging supplements that contain science-backed ingredients with proven efficacy and safety.

Customers Found the Supplement Effective

Reading about the experiences of people who took the anti-aging supplement is a great way to get the real details on the pros and cons, side effects, benefits, and more. All of the products our dermatologists chose got excellent reviews from users.

The Return Policy or Guarantee is Fair and Adequate

Companies that have faith in the quality of their products will offer you an adequate amount of time to try out the supplement to see if it works for you. Our team gave high points to brands that offer at least a 30-60 day return policy or money-back guarantee.

The Supplement is Worth the Price

The prices for anti-aging supplements tend to vary quite widely, but what our experts evaluated was whether the ingredients and benefits offered were worth the price. Then the team compared with other similar brands.

The Company Follows Strict Safety Practices

Ideally, you should buy from a company that manufactures, tests, and packages in an FDA-registered facility that follows GMP safety guidelines.

How Do The Best Anti-Aging Supplements Work?

The best, scientifically proven anti aging supplements recommended by dermatologists have collagen and elastin boosting ingredients to replace the levels that decline with age. This tightens the skin, improves elasticity, and smooths the surface to decrease the depth of wrinkle and fine lines.

A systematic review of the research published in the Journal of Drugs and Dermatology by Franchesca D. Choi, et al found that oral collagen supplements speed up wound healing and enhance skin elasticity, hydration, and collagen levels [2].

Anti-aging supplements contain very hydrating ingredients which deeply moisturize the complexion and get rid of dry patches and flaking, as we explained in our article on the Richest Hand Creams and Serums.

An article in the Journal of the American Academy of Dermatology discussed the benefits of moisturizers in healing and preventing skin dryness [3].

In addition, the added liquid gets under the skin and plumps it up, helping to further smooth signs of age. Many of these products have ingredients which slow production of the pigment melanin in the skin, which may lighten dark spots and hyperpigmentation.

Anti-aging supplements are rich in anti-inflammatory properties, so they help decrease swelling and heal skin conditions.

An article by researchers Tzu-Kai LinLily Zhong, and Juan Luis Santiago published in the International Journal of Molecular Sciences examined the anti-inflammatory potential and skin repair benefits of certain plant oils [4].

The anti-aging supplements are also rich in antioxidants which kill harmful free radicals on your skin to decrease oxidative stress. They heal and repair the skin barrier, and protect it from environmental agents like dust, smoke, and the sun’s rays.

What Are Some of the Ingredients To Look For?

These are some of the key ingredients you should look for in the best anti-aging supplements:

Vitamin C

This is a potent nutrient with powerful antioxidant properties, and it can repair damage to the skin barrier, protect from UV rays, and decrease redness and inflammation. It also boosts collagen synthesis for tighter skin with fewer wrinkles and lines.

An article by Yong Chool Boo published in Antioxidants examined emerging and combination therapies in the use of Vitamin C to increase collagen levels for skin anti-aging [5]. Vitamin C also blocks the production of melanin, which helps to lighten the skin and fade dark spots and hyperpigmentation.

Hydrolyzed Collagen

This is collagen in small pieces, which makes it very easy for the skin to absorb. It tightens the skin, improves elasticity, and helps to smooth wrinkles and fine lines. Collagen also boosts moisture levels to decrease dryness and plump the complexion for added youthfulness.

A 28-day study on adult volunteers published in The Journal of Clinical and Aesthetic Dermatology by Ferdinando Marco Bianchi, MD, et al found that taking hydrolyzed collagen led to improvements in skin hydration, elasticity, and wrinkle depth [6].

Hyaluronic Acid

This substance is already a part of the skin, eyes, and connective tissue as a hydrating agent. With age levels decline, which could lead to a dry complexion.

The added HA draws huge amounts of liquid for plump, moisturized skin and a decrease in the depth of wrinkles and lines. A literature review published in Dermatologic Therapy by Bruna Bravo, et al concluded that hyaluronic acid has great benefits for skin anti-aging [7].


These are lipids which already exist in our skin, and they make up about 40-50% of the outer layer. They form a protective barrier which keeps moisture in, so the skin stays hydrated, and the barrier also keeps out germs and harmful bacteria.

The liquid plumps the skin, giving it more volume so it decreases the depth of wrinkles and fine lines. A research review published in Cosmetics by Emine Kahraman, et al looked at recent advances on the use of ceramides for restoring skin barrier function [8].

What are the Benefits of Anti-Aging Supplements and Vitamins?


Many supplements contain high doses of antioxidants like vitamins C and E. This can help fight free radicals and reduce oxidative stress on skin cells. As a result, it can slow signs of aging over time.

Collagen Production

Certain supplements have ingredients that support collagen production, like vitamin C, copper, and silica. More collagen in the skin can help reduce fine lines and wrinkles.


Supplements boost hyaluronic acid in the skin, which helps the skin stay plump and hydrated. Dehydrated skin tends to look older.

Sun Protection

Supplements with antioxidants, vitamins C and E may provide some protection against sun damage from UV rays. This can help prevent premature aging from sun exposure.

Cell Turnover

Ingredients like vitamins A and B3 support cell turnover, which allows skin to shed old cells and produce new, healthier cells. This can improve skin clarity and texture.

Circulation Support

Nutrients like vitamins B3, B6, and B12 support circulation, bringing oxygen and nutrients to skin cells and removing waste. Better circulation may enhance skin health and a youthful appearance.

Multivitamin Benefits

A daily multi provides baseline nutrition and fills in dietary gaps, which is important for overall skin health and resilience against aging signs.


Q: Do Any Anti-Aging Supplements Work?

A: Yes, many anti-aging supplements work very well, including the brands our experts recommended in this article. However, you do have to do your homework if you look for other products, using the criteria we gave you: ingredients, manufacturer, safety, customer reviews, value for cost, guarantee, and other features and benefits.

Q: Where Can I Buy Anti-Aging Supplements?

A: Anti-aging supplements are for sale from a number of online retailers and stores. While not every skincare company offers a supplement, many do, and these products are widely available.
The prices of supplements can differ quite a lot and may range from about $30-$100 depending on the brand.

Q: What Are the Best Anti-Aging Supplements?

A: Our favorite is Beverly Hills MD Dermal Repair Complex for its rich, science-backed pure organic formula, but our experts have recommended a number of excellent products in this article which offer powerful anti-aging benefits for the skin.

Q: Who Should Take Anti-Aging Supplements?

A: Anti-Aging Supplements are ideal for those who are already seeing wrinkles, lines, and other signs of age on their skin. However, they are also a good idea for younger people who want to prevent premature aging, so you can begin taking these supplements in your 20s if you wish.

Q: Do Anti-Aging Supplements and Vitamins Stop Aging?

A: Aging can’t be prevented, but you can delay it and reduce the chances of age-related illnesses by using supplements, being active, and living healthily.

Q: At What Age Should I Start Taking Anti-Aging Supplements?

A: Most people start thinking about anti-aging supplements when they see wrinkles or feel aches and memory decline. You can begin taking antioxidants like resveratrol, curcumin, and CoQ10 in adulthood, and for some, it’s wise to start earlier due to factors like sun damage or smoking. While anti-aging supplements won’t reverse aging, they can help. Starting early to reduce inflammation and stress is key.

Q: How Often Should You Use Anti-Aging Supplements and Vitamins?

A: The frequency of using anti-aging supplements and vitamins can vary. It depends on the specific supplement and your age. Generally, it’s best to follow the recommended usage instructions on the product label or consult with a healthcare professional for personalized advice.

Q: What Are Some Natural Methods For Decreasing Skin Aging?

A: In addition to taking an anti-aging supplements, there are lifestyle choices you can make which can have a significant anti-aging impact on your skin. Try some of these suggestions:

  • Follow a healthy, nutrient and antioxidant rich diet and avoid refined sugar, unhealthy fats, and processed foods.
  • Try to lower levels of stress in your life, as it can cause damage to the skin leading to premature aging. Try getting a regular massage, practicing yoga, or taking a course in mindfulness and meditation.
  • Protect your skin from the sun by wearing a high SPF sunblock every time you go outside, and you may also consider sunglasses and a hat.
  • Exercise on a regular basis to improve circulation, which brings oxygen and nutrients to the skin for improved health.

Quick Comparison Table

Product Rating Best For Key Ingredients Return Policy
Beverly Hills MD Dermal Repair ComplexBeverly Hills MD Dermal Repair ComplexPrice. $39.95 Rating Best anti-aging supplements 2024 Hydrolyzed Collagen, Vitamins A and B, MSM, Hyaluronic Acid, Saw Palmetto 60-Day Guarantee
ActivatedYou Essential Skin FoodActivatedYou Essential Skin FoodPrice. $49 Rating Best Rated Anti-Aging Supplement Dermaval, Vitamin C, Triple Amino Acid Complex, Cosmythic 90-Day Return policy
Paula’s Choice Beauty SupplementPaula’s Choice Beauty SupplementPrice. $100.80 | 60 Capsules Rating Best antioxidant supplements for skin Hyaluronic Acid, Acai, Goji, Mangosteen, Cranberry, Strawberry 60-Day Return Policy
ResveraCel by ThorneResveraCel by ThornePrice. $54 Rating Best for Hormone Support Nicotinamide, Riboside, Hydrogen Malate 90-Day Return policy

Anti-Aging Supplement Reviews

We think that ActivatedYou Essential Skin Food is a quality supplement, and very reasonably-priced for the market. Out of 102 reviews on Amazon, it got a rating of 3.7 stars out of 5, and the average rating on the official site was 4.5 out of 532 reviews.

One of the best reviews on the official site is from ‘Satisfied Customer,’ who talked about how vibrant the supplements made her skin:

“I added essential skin care to my other activated you products, morning complete and daily digestive two months ago. I am noticing my skin is smoother looking not only on my face but legs as well. I have been getting a lot of compliments on how well I am looking so happy days”

One of the most critical reviews was from ‘Amazon Customer’ who mentioned having broken skin from these supplements:

“It doesn’t work. I was disappointed . After 6 days as me was taking it, my skin broke out sooo much. I stopped after 10!days using it, it didn’t get better.”

In the opinion of our dermatologists, Beverly Hills MD Dermal Repair Complex is a leading brand on the market which got great feedback from users. Out of 172 comments on Product Review.com, customers gave this supplement a 4.6/5 stars. On Google reviews, the product got an average rating of 4 out of 5 stars.

On of the best reviews comes from Nancy J on Product Review, who described a great reduction in the aging lines on her face:

“Excellent Product: I have been using the filler for about a month now. I especially see improvement around my eyes and frown lines.”

A critical review from ‘C’ on Amazon said they got few results, and this was disappointing: “Easy on stomach. I didn’t notice a difference in my appearance 😕 I’m finishing them but not getting more. Sorry.”

*Individual results can and will vary.


Anti-aging supplements aim to tighten the skin, improve elasticity, and smooth wrinkles, fine lines, and other signs of age like dark spots on the skin. The best products boost collagen and elastin, deeply hydrate, and promote a healthy, youthful glow.

In this article we have give you all of the pertinent details about supplement for anti-aging, along with our list of the best anti-aging supplements recommended by dermatologists.

You should be able to find one that meets your needs, or you can use the criteria we gave you to research other brands. If you want to have a look at some collagen supplements for skin, read our article on the best collagen supplements.

Michelle May, MS, RD, LD

By Michelle May, MS, RD, LD

Experienced Clinical Dietitian with a demonstrated history of working in the food & beverage industry.

13 sources

[1] These 13 Supplements Have Age-Reversing Effects: https://thethirty.whowhatwear.com/anti-aging-supplements/slide2
[2] Oral Collagen Supplementation: A Systematic Review of Dermatological Applications: https://pubmed.ncbi.nlm.nih.gov/30681787/
[3] Skin Moisturizers: Therapeutic Potential And Preventative Maintenance Of Dry Skin: https://www.jaad.org/article/S0190-9622(07)01815-4/fulltext
[4] Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796020/
[5] Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies: https://www.mdpi.com/2076-3921/11/9/1663
[6] Evaluation of the Efficacy of a Hydrolyzed Collagen Supplement for Improving Skin Moisturization, Smoothness, and Wrinkles: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8944283/
[7] Benefits Of Topical Hyaluronic Acid For Skin Quality And Signs Of Skin Aging: From Literature Review To Clinical Evidence: https://onlinelibrary.wiley.com/doi/10.1111/dth.15903
[8] Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin: https://www.mdpi.com/2079-9284/6/3/52
[9] Collagen Supplements for Aging and Wrinkles: A Paradigm Shift in the Fields of Dermatology and Cosmetics: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824545/
[10] The Roles of Vitamin C in Skin Health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579659/
[11] Hyaluronic Acid: A Key Molecule In Skin Aging: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/
[12] Vitamin A and Skin Health: https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-A
[13] Role Of Antioxidants In The Skin: Anti-Aging Effects: https://pubmed.ncbi.nlm.nih.gov/20399614/