Health & Wellness Products

Nucific Bio-X4 Reviews – Does Nucific Bio X4 4-in-1 Probiotic Supplement Work?

Bio X4 contains 12 billion CFUs, from 5 powerful Lactobacillus and Bifidobacterium probiotic strains, to help ensure smoother, more comfortable digestion.
By Dermspotlight Staff,
Updated Nov 12, 2022
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What is Bio X4?

Bio-X4 is a 4 in-1 probiotic for weight loss management that works to help optimize the digestive system from the inside out.

Every single Nucific Bio X4 capsule is packed with 4 nutrients that work together to provide your body with plenty of health benefits, leaving you feeling your best.

The supplement claims to help balance your digestive system, curb your cravings for unhealthy food, supercharge your metabolism, and support a healthy weight loss journey. Perhaps perusing over a few Bio X4 before and after pictures gives the impression of what to expect.



BEST FOR: Weight Management

USES: It helps boost metabolism, promotes digestive health, promotes immunity, and more so improves weight loss.

ACTIVE INGREDIENTS: Green Tea Extract, Digestive Enzymes, Probiotics, and more

PRICE: $99.00 per bottle

TYPE: Supplement

FORM: Capsule

ABOUT THE BRAND: Bio X4 is a product by Nucific in close partnership with Dr. Amy Lee who is a board-certified medic in the US.

WHERE TO BUY: Official Website


What Are the Benefits of Bio X4?


  • This product claims to support smoother digestion
  • It may also boost metabolism
  • It claims to promote weight management
  • The supplement may help you manage the craving for junk food

What are the Drawbacks of Bio X4?


  • There are safety concerns regarding ingredients like EFCCG green tea extract
  • You may find the supplement is expensive for a 30-day supply
  • It is only available through the company’s website

How Does Bio X4 Work?

Healthy digestion is key if you want to maintain a healthy weight. That is why this revolutionary 4-in 1 formula is designed in a way that works from the inside out.

That is, Nucific Bio-X4 reviews Dr. OZ contain digestive enzymes responsible for easy digestion and maximization of nutrient absorption. It also contains Caralluma Fimbriata that suppresses your appetite.

The supplement also contains blend green tea extract (EGCG) known to supercharge your body’s metabolism rate.

There is also a potent probiotic in this supplement responsible for balancing gut bacteria in your digestive system.

Bio X4
Nucific Bio X4 4-in-1 Weight Management Probiotic | Image/Dermspotlight

What are the Ingredients in Bio X4?

Top on the list of Bio X4 ingredients we have the following blends;

Lactobacillus Blend

This is a group of good bacteria known to support smooth digestion and you’re body’s general health. This probiotic blend consists of 3 specific Lactobacillus strains namely; rhamnosus, acidophilus, and Plantarum.

Our body naturally has Lactobacillus bacteria that aids in the management of digestive issues. Lactobacillus rhamnosus has been found to improve digestive-related symptoms like diarrhea and constipation. However, if these strains are not balanced, they can affect our health.

One of the Hindawi Journals has revealed that Lactobacillus Plantarum can support a healthy digestive tract as well as the microbiome.

Bifidobacterium Blend

Bifidobacterium is among the major bacteria lining strains found in the gastrointestinal tract. Bio X4 consists of 2 specific Bifidobacterium strains namely; animals and lactic.

A small research study conducted in 2010 revealed that Bifidobacterium lactis can be used to reduce gastrointestinal-related symptoms like constipation.

According to Microorganism Journal, Bifidobacterium animalis was found to have a protective effect on diarrhea and in the management of antibiotic-associated with diarrhea.

Digestive Enzyme Blend (43 mg)

This blend contains 3 digestive enzymes namely; lipase, amylase, and bromelain. Amylase is responsible for breaking down carbohydrates while lipase breaks down body fat. Bromelain enzyme addresses digestion-related problems.

Bromelain is found in pineapple while lipase and amylase are found in food like papayas, bananas, avocados, and mangoes.

While all these enzymes are important, there is no need of taking supplements not unless a person has a deficiency.

According to Biotechnology Research International, Bromelain has been found to support protein digestion, including other health benefits like improving respiratory conditions.

Weight Management Blend (100mg)

This weight management blend consists of green tea extract (EGCG). This particular compound is known to burn body fat and also boost the level of metabolism in the body.

Though the researches done about this bend is mixed some have shown that this blend supports body fat burning, especially if you take at least 270 mg of EGCG every day.

According to Advanced in Nutrition: An International Review Journal, Green Tea Extracts (EGCG) can be used to improve fat metabolism.

Craving Control Blend (166g)

Bio-X4 is said to contain a craving control blend known as slimaluma. Its real name however is Caralluma Fimbriata and is extracted from an Indian native cactus. There have been studies claiming that this extract is good at controlling hunger for food.

However, according to the studies, this effect has only been noticed in children with certain appetite disorders known Prader-Willis syndrome.

According to a research study in Appetite Journal, Caralluma Fimbriata extract has been found to suppress appetite and also reduce waist circumference.

How Should I Take Bio X4?

The recommended Bio X4 dosage is one capsule 3 times a day.

How To Take: Take 1 capsule with each meal, 3x a day. Can take up to 2 capsules per meal.

What is the Return Policy for Bio X4?

This product comes with a 90-day 100 money-back guarantee. If for some reason you are unhappy with the product, you can return it and you will get a full purchase price without hassle.

Bio X4 – FAQs

Q: Does Bio X4 Work?
A: Yes, Bio X4 works. It is a nutritional supplement that effectively supports weight management regardless of gender, age, eating habits, or body type.

Q: Is Nucific Bio X4 FDA Approved?
A: FDA does not approve dietary supplements. However, the product has been developed by a renowned qualified doctor and tested by a third party to show authentic the product is.

Q: What is Bio X4 Good for?
A: This general wellness supplement with many health benefits including digestive support, immune health, and more.

Q: Does Bio X4 Contain Caffeine?
A: No, caffeine is not among the ingredients found in Bio X4. However, it contains green tea extract which also belongs to a stimulant family.

Q: Is Bio X4 Safe for Diabetics?
A: This product contains no added sugars. However, we advise diabetic patients to seek the advice of a professional health provider before adding this supplement to their regimen.

Q: Where Can I Buy Bio X4, is it Available In Stores?
A: Bio X4 is available for the purchase of the brand’s official website. The cost of the product is as follows:

  • 1 bottle pack – $99.00
  • 3 bottle pack – $261.36
  • 6 bottle pack – $487.08

What You’ll Get:

  • Free Shipping On All US Orders Over $50.
  • 90-day, 100% money back guarantee.

Q: Is Bio X4 Legit or a Scam?
A: Bio X4 is absolutely a legitimate product.It has an official website where you can get all the necessary information about the company, including contact information like a phone number.

According to the information available on the official website, Nucific is an accredited business and also has its presence on various social media platforms. As a result, there are no indications of a Bio X4 scam.

Q: When Should Bio X4 be Taken?
A: Since Nucific Bio X4 is taken 3 times a day, you should take one capsule in the morning, one during the daytime, and another one in the evening.

According to the manufacturer, every Bio X4 capsule contains natural ingredients known to be gentle on your digestive system but still provides you with visible results.

Note: Do not exceed 6 capsules a day.

Q: Are There Any Bio X4 Side Effects?
A: The manufacturer’s official website claims that there are no known Nucific Bio X4 side effects. Bio-X4 is 100% gluten-free and allergen-free, it is compatible with any diet. Also, there were no mentions of symptoms in any of the Bio X4 reviews online.

Q: Does Bio X4 Cause Diarrhoea?
A: No, Bio X4 does not cause diarrhea. According to the manufacturer, this supplement contains Bifidobacterium animalis and has a protective effect against diarrhea, and also manages antibiotic-related diarrhea.

Nucific Bio-X4 Customer Reviews

Find helpful customer reviews for Nucific Bio-X4 4-in-1 Weight Management Probiotic Supplement, 90 Count.

Bio X4 pill is helping me suppress my hunger
I’ve been using the pill for almost a month now and I feel that it has been helping me to suppress my hunger longer and when using it as directed on the bottle it gets me full even before I start eating my meal. I’m liking it because it makes me eat less and helps elemental what I need too. Franslyn Gascon.

Excellent choice I made ordering
So happy with Bio X-4. Been taking it for about 30 days now and the results in my digestion system have not felt this good since I was a child. I have been on flow max for prostate issues for 2 years now and it helped a little. But since taking Bio X-4 I couldn’t be happier. No more upset stomachs, I got energy and working ou again. Honestly, don’t know about weight but I have not felt this good in a long time. I’m 41 years old and feel great again. Thanks for everything. I highly recommend Bio X-4. James.

Bio-X4 review
I haven’t been using it for that long and I got mixed instructions about directions so I haven’t been using the product properly for long. I will continue using this product as I do feel better but no significant changes yet. My biggest problem is remembering to take it before each meal. Kelley Dentremont.

Sharing results of Nucific Bio X4
I have not experienced any jitters or strange feelings. I have noticed my appetite is reduced. I also feel my digestive system is continually cleansing. So far Bio-X4 has been helping as promised. Thank you Melinda O’Quinn.

Bio X4 Alternatives: How Does It Compare with Other Products?

Product Price Ingredients
Vital Reds $69.95 Green tea, Aronia Berries, Grape Seed Extract, Mulberry Extract, Bitter Melon Extract
Bio Complete 3 $69.95 Bacillus Coagulans, Sunfiber, Tributyrin
ActivatedYou Morning Complete $79.00 Prebiotic and High Fiber Blend, Green Superfoods Blend, Antioxidant Blend, Fennel Seed
Active PK $89.95 Berberine HCL, Quercetin Dihydrate

How Does Nucific Bio X4 Rate?

Feature Rating
Ingredients 4.8
Manufacturer 4.8
Benefits 4.9
Price 4.8

Nucific Bio X4 Review – Conclusion

While the product can effectively optimize your digestive health on its own, taking the probiotic supplement combined with regular exercise and healthy diety can go a long way in helping you realize faster and more dramatic results.

Also, the digestive system of every person is different, meaning that results may vary from one individual to the other.

For optimal results, ensure that you use the supplement consistently and as directed by the manufacturer.

Where to Buy Nucific Bio X4?

The product can be bought from the official website

SEE ALSOLCR Health Active PK and ActivatedYou Morning Complete


[1] Metabolic Determinants of Weight Gain in Humans:
[2] Probiotic research priorities for the healthy adult population: A review on the health benefits of Lactobacillus rhamnosus GG and Bifidobacterium animalis subspecies lactis BB-12:
[3] The intestinal microbiota in health and disease:
[4] The Impact of Lactobacillus plantarum on the Gut Microbiota of Mice with DSS-Induced Colitis:
[5] Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults:
[6] The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®
[7] Properties and Therapeutic Application of Bromelain: A Review:
[8] The Effect of Green Tea Extract on Fat Oxidation at Rest and during Exercise: Evidence of Efficacy and Proposed Mechanisms:
[9] Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women:
[11] Exercise Modifies the Gut Microbiota with Positive Health Effects: