What is Drmtlgy Peptide Night Cream?

This enriching nighttime formula from Drmtlgy is infused with a rich blend of plant-based ingredients high in peptides and ceramides. Drmtlgy Peptide Night Cream nourishes and hydrates the skin as you sleep, and it also tightens and firms to smooth fine lines and wrinkles.

Top dermatologists formulated this cream, and many others recommend it for its enriching anti-aging and moisturizing properties.

Personally this is my go-to nighttime cream, and I love waking up with a refreshed, youthful looking complexion. Let’s look at some of the details of this luxurious beauty product.

Brand Highlights

  • Peptide Night Cream is suitable for vegetarians and vegans.
  • It’s free of gluten, parabens, sulfates, oil, and fragrance.
  • The formulas are dermatologist-developed and approved.
  • They contain 100% organically-sourced ingredients.

Fast Facts

Peptide Night Cream

Best For: All Skin Types
Uses: Hydrates skin, firms to smooth fine lines and wrinkles
Active Ingredients: Ceramides, Shea Butter, Peptides, Cholesterol, Allantoin, Vitamin E
Price: $46
Age Group: Adult
About The Brand: The brand manufacturer is a company called Drmtlgy LLC, which is a highly reputable skincare organization located in Los Angeles, California. Founded in 2017, they offer a large collection of medical grade skincare.
Where To Buy: Official Website

Pros and Cons of Drmtlgy Peptide Night Cream


  1. It can restore the overall health of the skin.
  2. Peptide Night Cream formula can smooth wrinkles and fine lines.
  3. This product locks in moisture for longer benefits.
  4. This cream can repair damage to the skin barrier.
  5. It protects from UV rays and other harmful agents.


  1. The results will vary for different individuals.
  2. There are no free product samples available.
  3. You can only buy Peptide Night Cream online.

How Does This Repair Night Cream Work?

The Peptide Night Cream formula includes 5 powerful peptides which stimulate collagen and elastin production. This leads to tighter skin with improved elasticity, because it replaces some of the collagen and elastin levels that have depleted with age.

This night cream is incredibly hydrating, and it moisturizes your skin at night when there are less outside influences, getting rid of a dull, dry texture. It also gives the skin more volume, further smoothing lines. Health expert Sazan Sylejmani says “these creams are excellent for direct, visible results and usually contain ingredients like retinol for speeding up cell turnover, vitamin C for collagen production, and ceramides to restore barrier function which are crucial for reducing wrinkles.”

A review in the Indian Journal of Dermatology explored the key role that moisturizers play in dermatology. [1]

In addition, this cream can form a barrier which locks in moisture for a longer period of time. It also keeps out harmful agents like bacteria and other microbes. Its anti-inflammatory benefits reduce swelling and redness and may help heal skin conditions.

Drmtlgy Peptide Night Cream is replete in antioxidants which function to eliminate free radicals on the skin, lowering oxidative stress. This raises the overall immunity, helps to heal the skin barrier, and protects from UV rays and other environmental stressors.

A review article in Oxidative Medicine and Cellular Longevity explored the role of antioxidants in the prevention and treatment of skin cancer. [2]

What Are the Peptide Night Cream Ingredients?

According to Chelsey Borson “while choosing the night creams for wrinkles, look for ingredients like retinol, hyaluronic acid, and peptides in anti-wrinkle creams. Retinol helps with cell turnover and stimulates collagen production. Hyaluronic acid hydrates and plumps the skin, while peptides stimulate collagen synthesis.” Have a look on some of the Drmtlgy Peptide Night Cream key ingredients:


Ceramides are fatty lipids that are found naturally in the top layer of the dermis, and they make up about 30-40% of that layer. As discussed in our Drmtlgy Eye Cream Reviews article, Ceramides hydrate the skin and form an impermeable barrier to prevent liquid from escaping and germs from entering. They can repair damage to the skin barrier, promotes hydration, decrease inflammation, and protect from UV rays and other harmful agents.

A reviews in the American Academy of Dermatology went over the structure, function, and uses of ceramides as therapeutic agents in skin care. [3]


This fatty substance already exists in the body, serving many roles including building the cell membranes ad balancing hormone levels. It’s a fast-penetrating substance which hydrates the skin and also softens it deeply. It’s known to be easy on the skin, and suitable for people who are sensitive.

An article in the Journal of Lipid Research discussed the key role of lipid metabolism in the complexion. [4]

Without sufficient cholesterol, skin can become dry, cracked and easily irritated, leading to premature aging and other skin problems says Dr. Rachel Nazarian [5].


Peptides are strings of amino acids that produce proteins, including collagen and elastin. Replacing these key proteins in the skin makes it tighter, more elastic, and smooths wrinkles and lines as documented in our Needle-less Serum Drmtlgy Reviews article. Peptides also hydrate the skin, improve immunity, and help with protection and repair.

A study in Food and Function indicated that collagen peptides could promote photoaging skin cell repair and decrease collagen degradation. [6]

Peptides are short chains of amino acids that can communicate with skin cells and trigger various biological processes says Dr. Joshua Zeichner [7].

Shea Butter

This rich, hydrating butter is a staple in many face and body creams. Rich in both anti-inflammatory agents and antioxidants, it can repair, protect, and help heal wounds and skin conditions. In addition, it’s deeply soothing to the complexion.

A study in Clinical, Cosmeceutical, and Investigational Dermatology found that a moisturizer with shea butter was safe for subjects with sensitive skin. [8]

Shea butter has anti-inflammatory properties and is rich in vitamins A and E, which help to nourish and protect the skin from environmental stressors. It’s also rich in essential fatty acids, which help to repair and maintain the skin’s natural barrier function says Dr. Hadley King [9].

Peptide Night Cream (FAQs)

Q: Is Drmtlgy Brand Cruelty-Free?

A: Yes, one great feature of the Drmtlgy brand is that they are 100% cruelty free. They will never test on animals, work with associates or suppliers who do, or sell in parts of the world where animal testing is legalized.

Q: Is Peptide Night Cream Worth It?

A: If you consider the quality of this night cream and its high content of peptide and ceramide ingredients, the price is incredibly reasonable. I gladly pay for the rich benefits this cream has to offer, and most of the Drmtlgy Peptide Night users felt the same way. The Peptide Night Cream reviews raved about this cream.

Q: How to use Drmtlgy Peptide Night Cream?

A: You can use DRMTLGY Peptide Night Cream by simply applying a small amount of cream to your face and neck before bed. Gently massage the cream into your skin until it is fully absorbed.

Q: Where to Buy Peptide Night Cream?

A: This peptide-based night cream is available on the manufacturer’s official website, as well as from a number of other online retailers, like Amazon. It costs $46 on the official site if you make a one-time purchase, and 37% if you subscribe. If you click on the top link, you can get an extra 20% off sent to your mobile.

Q: What is the Drmtlgy Peptide Night Cream Return Policy?

A: This manufacturer is offering a generous a 60-day return policy. If you are not happy with your purchase, contact the customer service department for instructions, then send the product back within 60 days of the purchase. You should get a full refund, but the customer pays the return shipping costs.

Q: Is DRMTLGY Peptide Night Cream suitable for all skin types?

A: Yes, the DRMTLGY Peptide Night Cream is generally suitable for all skin types, it’s always a good idea to perform a patch test before using it, especially if you have sensitive skin. This can help ensure that the product won’t cause any adverse reactions or irritation.

Q: What Sets Peptide Night Cream Apart From the Competition?

A: This is a high-quality cream from a high-quality brand, made by dermatologists and using science-backed ingredients. This immediately sets it apart from many of the similar creams for sale today.

Drmtlgy Peptide Night Cream Reviews – What Do Real Users Say?

I found the night repair cream customer reviews to be very positive, and most people said they used it regularly and it did amazing things for their skin, including getting rid of fine lines and dryness. I selected some of the best Drmtlgy Peptide Night Cream reviews.

Favorite Night Cream

I love the texture of this cream. It’s light and fluffy, yet still hydrates my skin wonderfully. I tried other creams but either they’re too heavy and sit on my face without absorbing, or they’re too light and don’t moisturize. This hits the sweet spot for me!

Mardee M..

Peptide Night Cream

I love that I can wear this in the am and pm. A little goes a long way. I use it on my face, chest and started rubbing the leftover on the tops of my hands. I wake up with beautiful skin.

Marie .P.

Lightweight But Hydrating

I love the formulation of this cream. It is lightweight yet goes on so luxuriously on my skin. I have very sensitive skin, and it often feels parched, tight, and dry after a full day in an air-conditioned room.

This hydrates my skin really well; I use a huge dollop each time and gently massage it in. It just melts into my skin. Will highly recommend.


Official Video of Peptide Night Cream | Drmtlgy

How Does It Compare with Other Brands?

Brand Price Ingredients Return Policy
SkinCeuticals Triple Lipid Restore $162 Peppermint, Lavender, Cholesterol, Ceramides, Rosemary, Fatty Acids 30-Day 100% Satisfaction Guarantee
Kiehl’s Midnight Recovery Cream $53 Fatty Acids, Rosemary Oil, Lavender Oil, Jojoba Oil, Squalane Open 100% Money Back Guarantee

How Does Peptide Night Cream Rate?

Feature Stars
Ingredients 5 Stars
Manufacturer 5 Stars
Safety 4.7 Stars
Price 4.8 Stars

Drmtlgy Peptide Night Cream Review – Conclusion

This night cream is rich in peptides, ceramides, and some other organic and deeply hydrating ingredients which keep the skin firm, moisturized, and free of fine lines and wrinkles. Made by Drmtlgy, a top manufacturer, this formula is highly effective and is also reasonably-priced.

Drmtlgy makes a high-quality anti-aging night cream, and the reviews make that very clear. Both the feedback on the official site as well as comments on independent sites were from happy customers who use this cream on a regular basis to keep their skin refreshed and youthful-looking.

The Peptide Night Cream formula includes only 100% organically-sourced ingredients, with no gluten, sulfates, parabens, fragrance, or other potentially harmful additives. The product should not lead to any side effects. As both a reviewer and a customer, in my opinion this is one of the top night creams on the market – and way worth the cost.

Where to Buy?

Check the Official Website to Purchase this Product.

9 sources

[1] Moisturizers: The Slippery Road: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885180/
[2] The Role of Antioxidants in the Prevention and Treatment
[3] The Structure, Function, And Importance Of Ceramides In Skin And Their Use As Therapeutic Agents In Skin-Care Products: https://pubmed.ncbi.nlm.nih.gov/24656726/
[4] The Outer Frontier: The Importance Of Lipid Metabolism In The Skin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674689/
[5] Dr. Rachel Nazarian, a dermatologist at Schweiger Dermatology Group in New York City https://www.instagram.com/drrachelnazarian/
[6] Collagen Peptides Promote Photoaging Skin Cell Repair By Activating The TGF-?/Smad Pathway And Depressing Collagen Degradation: https://pubs.rsc.org/en/content/articlelanding/2019/fo/c9fo00610a
[7] Dr. Joshua Zeichner, Director of Cosmetic and Clinical Research in Dermatology at Mount Sinai Hospital in New York City. https://www.instagram.com/joshzeichnermd/
[8] Skin Acceptability Of A Cosmetic Moisturizer Formulation In Female Subjects With Sensitive Skin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933397/
[9] Dr. Hadley King, a board-certified dermatologist in New York City https://www.instagram.com/drhadleyking/