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21 Best Wrinkle Creams (Top Anti-Aging Serum, Lotion & Moisturizer), According to Dermatologists

Discover the best wrinkle creams and serums on the market that really work to remove wrinkles. Give your skin a boost with these anti-aging skin care products.
By Dermspotlight Staff,
Updated January 15, 2021
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Which wrinkle creams really work?

The article aims to provide you with the top 15 anti-aging creams and wrinkle serums on the market, according to our evaluation. We’ll give you a summary of each product as well as information about how to use these items most effectively. These are the wrinkle creams for men and women that we think really work well and would recommend.

What are the best anti-aging ingredients?

There are numerous excellent ingredients for anti-aging cream. These are a few of the top active ingredients:

  • Hyaluronic Acid: Hyaluronic acid is a humectant, meaning that it attracts moisture. The body utilizes hyaluronic acid to maintain our the skin’s hydration. This moisture supports skin volume and combats wrinkles. An article published in Dermato-Endocrinology examined hyaluronic acid as a key molecule in skin aging.
  • Retinol: Retinol is a vitamin A derivative that stimulates cell turnover and collagen production. Regular retinol use helps to reduce the appearance of fine lines, evens out complexion, and unclogs pores. A study published in the International Journal of Cosmetic Science found that retinol has remarkable anti-aging properties.
  • Vitamin C: Also called ascorbic acid, this vitamin is essential for the body. Vitamin C is a potent antioxidant that can neutralize free radicals. In our skin, it helps to repair damage and protect from harm. It can also brighten complexion and prevent photoaging. According to the National Institutes of Health, it can also regenerate other antioxidants in the body.
  • Jojoba Oil: Jojoba oil comes from the jojoba plant and it contains wax esters, similar to the natural oils in our skin. It has powerful anti-inflammatory effects that can lessen swelling and redness. It contains healing antioxidants and is very hydrating for the skin. An article published in G Ital Dermatol Venereol looked at the role of jojoba oil in dermatology, and found it to be an excellent additive to our topical skin care products.

How to choose the best anti-aging wrinkle cream or serum

There are several factors to consider when choosing the best anti-wrinkle creams and serums. First of all, check that some of the ingredients for the anti-aging cream we have mentioned are in the product. Second, do your own personal research on the anti-aging benefits of each substance.

In addition, check out who the manufacturer is and make sure they have a good reputation. Read the reviews for the company and for the product, to see what other users have to say. Finally, compare with other products to see if they offer the same benefits.

Do over-the-counter wrinkle creams really reduce the appearance of fine lines and wrinkles?

This really depends on the ingredients included and the quality of the product. Before you purchase an anti-wrinkle cream, it is important to do your research about the product. Creams that include high-quality substances such as peptides, hyaluronic acid, squalane, and jojoba oil should be effective.

The Best Anti-Aging Creams and Serums for Wrinkles

Glé Skincare Wrinkle Cream

The anti-aging cream is especially made to treat the face, neck, and decolletage. It helps to eliminate wrinkles and fine lines and hydrate the skin deeply. This product contains many vitamins and is also high in healing antioxidants.

Glé Skincare Wrinkle Cream

Pros

  • The product is a great anti-wrinkle option for sensitive skin.
  • Younger people can use it for preventative purposes.
  • It can help remove the stubborn wrinkles around the mouth, crow’s feet, forehead wrinkles, and eyes.

Cons

  • As with any topical product, there’s a chance you could have an allergic reaction.
  • It’s unscented, which may be a con for some consumers.

Price

  • Single – $39.99
  • Double – $34.99
  • Triple – $ 32.99

Key Ingredients: Vitamin E, Algae, Vitamins B3 and B5, Jojoba Oil, Acetyl Hexapeptide 8

L’Oreal Revitalift Cicacream

This is a luxurious, lightweight anti-wrinkle cream with retinol, in addition to many other anti-aging ingredients. It contains an anti-wrinkle powerhouse called Centella Asiatica, which has long been used in Chinese medicine. It repairs damage to the skin barrier and protects it from further breakdown. It also firms the skin, which helps to diminish the appearance of wrinkles and fine lines.

L'Oreal Revitalift Cicacream

Pros

  • This cream helps to eliminate lines and wrinkles.
  • It’s a hydrating moisturizer.
  • The product may improve circulation, further improving skin health and appearance.

Cons

  • The product does not contain peptides.
  • As with any topical, you could have an allergic skin reaction.

Price: $17.99

Key Ingredients: Centella Asiatica, Butter, Cocoa Seed Butter, Tocopherol, Theobroma, Retinyl Palmitate

Olay Regenerist Micro-Sculpting Cream

Olay Regenerist Micro-Sculpting Cream is a rich formula made to combat the signs of age from the skin. It’s a deeply hydrating formula, which helps the skin to appear refreshed and rejuvenated.

The cream is rich in peptides, which helps stimulate collagen production, and in turn lessens the appearance of wrinkles. This is a well-known brand with an excellent reputation. It is also reasonably priced.

Olay Regenerist Micro-Sculpting Cream

Pros

  • The cream can help eliminate wrinkles and fine lines.
  • It can helps to retain moisturize and keep the skin hydrated.
  • The product should help give you younger-looking skin.

Cons

  • As with any topical, some ingredients may provoke allergies.
  • Some people may not like the fragrance.

Price: $26.78

Key Ingredients: Niacinamide, Amino-Peptide Complex, Carob Fruit Extract, Sodium Hyaluronate, Capric Triglyceride

SkinCeuticals C + AHA

This is an antioxidant-rich serum which combines Vitamin C and alpha hydroxy acids. It improves skin immunity and repairs damage to the skin barrier. The formula also protects the skin from future damage and from environmental toxins. In addition, this serum helps to exfoliate the skin which helps with blemishes and to even out skin tone.

SkinCeuticals C + AHA

Pros

  • It exfoliates the skin.
  • The product can improve breakouts and overall brightness.
  • It protects against environmental toxins.

Cons

  • This product is expensive for some consumers.
  • It’s less effective for wrinkle prevention for sensitive skin.
  • It’s a serum, which some may find oily.

Price: $136

Key Ingredients: Vitamin C and Alpha Hydroxy Acid

SkinMedica HA5 Rejuvenating Hydrator

This is an incredibly hydrating serum that contains 5 different types of hyaluronic acid. Such a moisturizing product helps to boost volume and smooths out wrinkles and fine lines. This product is also very high in antioxidants. According to the manufacturer, the results are immediate, which is rare for a skin product.

SkinMedica HA5 Rejuvenating Hydrator

Pros

  • It’s suitable for all skin types, including sensitive.
  • The product makes your skin tone more radiant.
  • It can eliminate fine lines and wrinkles.

Cons

  • This anti-wrinkle serum is quite expensive.
  • As with any topical, you could have an allergic reaction to an ingredient.

Price: $120

Key Ingredients: Vitis Flower Stem Cell Extract, Peptide Complex, Polysaccharides from French Polynesia, 5 Types of Hyaluronic Acid

N1 O1 Anti-Aging Serum

This is a unique anti-aging skin care cream that uses Nobel prize winning discoveries in its development. This product initiates the production of nitric oxide, which stimulates collagen production and restores the youthful flow of oxygen, hydration, and nutrients to your skin cells.

N1 O1 Anti-Aging Serum

Pros

  • This product is hypo allergenic.
  • It helps to oxygenate skin cells and restore function.
  • This cream makes the skin firm and helps to smooth wrinkles.

Cons

  • The product lacks some other key ingredients.
  • This is a very expensive product.
  • There are no reviews of anti-wrinkle cream online.

Price: $180

Key Ingredients: hydroxyethylcellulose, sodium nitrite, d-Tocopheryl Acetate, dehydroacetic acid, tetrasodium EDTA, Ascorbic Acid

SkinCeuticals Metacell Renewal B3 Serum

This cream is a rich peptide concentrate which increases collagen production, firming the skin and eliminating wrinkles and fine lines. It also contains ingredients that can give the skin a rosy glow and a younger look. The product is a little pricey, but customers have said that it works very well.

SkinCeuticals Metacell Renewal B3 Serum

Pros

  • The product can improve the signs of photoaging.
  • It can give the skin a more radiant appearance.
  • The product anti-wrinkle cream reviews were very positive.

Cons

  • The cream is very costly.
  • Some users say it goes on feeling sticky.

Price: $130

Key Ingredients: Glycerin, Niacinamide, Tri-Peptide Concentrate

Pause Complete Face Serum

Pause Complete Face Serum is for women who are struggling with menopause-related skin changes, including dryness, sagging, and dull complexion. The product can firm the skin and smooth wrinkles and lines. It’s very hydrating, which offers anti-aging benefits and also moisturizes the skin. Pause Complete Face Serum can also improve elasticity, enhance tone, and tighten the facial contours around the jaw.

Pause Complete Face Serum

Pros

  • It counteracts the effects on menopause on the skin.
  • It can lessen wrinkles and fine lines.
  • This cream keeps the skin moisturized.

Cons

  • It’s somewhat pricey.
  • Lacks some key ingredients.

Price: $85

Key Ingredients: Hydrolyzed Sesame Protein, Sodium Hyaluronate, Trifluoroacetyl Tripeptide2

Revision Skincare Intellishade SPF 45

The manufacturer calls this a 5-in-1 skin cream which can correct, protect, conceal, brighten, and hydrate skin. This cream can eliminate lines and wrinkles, enhance the skin’s natural moisture barrier, even out skin tone, and brighten the skin. In addition, it contains a 45 SPF skin protection which is key for preventing further photodamage.

Revision Skincare Intellishade SPF 45

Pros

Cons

  • As with any topical, you may have an allergic reaction to one of the ingredients.
  • Some people may not like that it’s tinted.

Price: $75

Key Ingredients: Three Peptides, Vitamin C, Zinc Oxide, Titanium Dioxide, Coenzyme Q10, Plankton Extract, White Birch Extract

StriVectin SD Advanced Plus Intensive Moisturizing Concentrate

This is a rich organic anti-aging cream with many peptides that produce 10 different types of collagen. This anti-wrinkle cream firms the skin and can help lessen wrinkles and lines in as little as 2 weeks. This product is also a rich moisturizer which hydrates and smooths the skin.

StriVectin SD Advanced Plus Intensive Moisturizing Concentrate

Pros

  • The product provides 72 hours of continuous moisture.
  • It can eliminate stretch marks in as little as a month.
  • This cream can help reduce wrinkles and frown lines within 2 weeks.

Cons

  • It has many ingredients, increasing the chance of an allergic reaction.
  • The product is somewhat expensive.

Price: $79

Key Ingredients: Hyaluronic Acid, Collagen-CE Complex™ with Copper Tripeptide and Marine Ferments, Green Bean Seed Extract, Tucuma, Cupuacu, and Murumuru butter, White Water Lily Extract

Jan Marini Regeneration Booster

This facial lotion has potent anti-aging properties. It’s high in antioxidants, which repair the skin barrier and improve the skin’s immunity. This cream can eliminate wrinkles and fine lines on the face and improve the skin’s tone and texture. The anti-wrinkle cream reviews for this product were overwhelmingly positive, with users raving about improvements in their skin.

Jan Marini Regeneration Booster

Pros

  • It can improve texture and skin tone.
  • The product can help eliminate fine lines and wrinkles.
  • It is high in antioxidants.

Cons

  • This is a very expensive product.
  • It has many ingredients, so it may cause an allergic reaction in some people.

Price: $215

Key Ingredients: Growth Factors, Peptides, and Antioxidants

Skin Better Science AlphaRet Overnight Cream

This is a popular night cream that helps repair skin damage and eliminate signs of age like wrinkles and lines, brown spots, and uneven skin texture. Key ingredients are retinoid and lactic acid. Retinoid promotes cell turnover and can also help fade dark spots. Lactic acid is an alpha hydroxy acid that works to improve skin tone and texture by gently dissolving dead skin cells. The formula also contains hydrating hyaluronic acid, glycerin, and niacinamide.

Skin Better Science AlphaRet Overnight Cream

Pros

  • It contains a lot of antioxidants which repair damage to the skin barrier.
  • It contains soothing ingredients like bisabolol and portulaca extract, to counteract any dryness.
  • It can reduce the depth and size of wrinkles by 4 weeks.

Cons

  • This product is quite costly.
  • Intended only for overnight use.

Price: $125

Key Ingredients: Peptides, Shea Butter, Niacinamide, Squalane, Green Tea Leaf, Retinoids, Alpha Hydroxy Acids

Le Lift Crème

This product is made by Chanel, which automatically indicates it is of the highest quality. The cream promises to promote a re-contoured, toned, and refined complexion. It contains Botanical Alfalfa Concentrate, an ingredient they claim is as efficient as retinol, that helps to smooth and firm the skin. It’s a little bit expensive, but more than likely it’s worth it for a Chanel product.

Le Lift Crème

Pros

  • This cream can improve wrinkles and fine lines.
  • It can refine the facial contours.
  • The product helps firm and smooths the skin.

Cons

  • There is only one primary active ingredient.
  • The second ingredient is alcohol, which can cause dryness and irritation.
  • It’s fairly expensive.

Price: $165

Key Ingredients: Botanical Alfalfa Concentrate

Kate Somerville ‘Quench’ Hydrating Serum

This is a facial serum that provides the skin with an immense amount of moisture. It helps enhance skin volume, helps to smooth out fine lines and gives your skin a lovely glow. The vast majority of the users loved this product.

Kate Somerville 'Quench' Hydrating Serum

Pros

  • It’s an excellent moisturizer.
  • The serum can lessen the appearance of fine lines.
  • It leaves your skin with a brighter appearance.

Cons

  • It has less ingredients than other similar products.
  • It’s meant exclusively for the face, not the neck or other areas.

Price: $75

Key Ingredients: HSC Complex, Lipids, Vitamin A

Murad Retinol Youth Renewal Serum

This is an anti-wrinkle cream with retinol, which is safe for all skin types including those with sensitive skin. The manufacturer notes that it is safe for all ages. They claim their clinical tests show that 93% of users had a reduction in wrinkles and lines after 2 weeks. Users also said they say a big difference in their wrinkles even after only a couple of weeks.

Murad Retinol Youth Renewal Serum

Pros

  • It’s a deeply hydrating formula which combats dryness.
  • This cream gives your skin a radiant glow.
  • It diminishes the appearance of wrinkles and fine lines.

Cons

  • It’s not suitable for vegetarians.
  • The fragrance or other ingredients could cause a skin reaction.

Price: $89, but save 10% with auto-delivery

Key Ingredients: Retinol, Hyaluronic Acid, Swertia Flower Extract, Retinol Tri-Active Technology

La Roche-Posay Pure Vitamin C Face Serum

This cream focuses on Vitamin C as its main active ingredients, which has powerful antioxidant properties. It can help repair skin damage and protect from additional harm. It’s also high in hydrating ingredients like hyaluronic acid, and anti-acne ingredients like salicylic acid. This product has brightening properties and can give the skin a radiant glow.

La Roche-Posay Pure Vitamin C Face Serum

Pros

  • It can exfoliate the skin improve the texture of skin.
  • This cream is very soothing to the skin.
  • It’s a rich moisturizer.

Cons

  • Some ingredients may lead to a skin reaction.
  • Not every user likes a cream with a fragrance.

Price: $59

Key Ingredients: Vitamin C, Hyaluronic Acid, and Salicylic Acid

SK-II Facial Treatment Essence

This cream uses the cultivation of one yeast strain that possesses anti-aging properties for the skin. It has over 50 rich micronutrients, which promote the health of the skin and boost cell metabolism. It is full of a moisturizing ingredients that hydrates the skin. Overall, it softens texture, reduces the appearance of dark spots and fine lines, evens the skin tone, and enhances visible radiance.

SK-II Facial Treatment Essence

Pros

Cons

  • The product is not a suitable anti-wrinkle cream for sensitive skin.
  • Lack of other beneficial ingredients.
  • It’s somewhat expensive.

Price: $99

Key Ingredients: Over 50 micro-nutrients like vitamins, minerals, amino acids, and organic acids, Galactomyces Ferment Filtrate

Sisleÿa Global Anti-Age Extra-Rich

This is a luxurious cream with ingredients that work to repair damage to the skin cells. They also restore and replenish the skin barrier, as well as protect it from further harm. This is a deeply moisturizing formula which eliminates dry skin and keeps it hydrated. The manufacturer promises that this product fights different types of skin aging.

Sisleÿa Global Anti-Age Extra-Rich

Pros

  • The cream can eliminate dry skin.
  • It can get rid of wrinkles and fine lines.
  • The product can give the skin a radiant appearance.

Cons

  • This is a very expensive product.
  • It’s missing some ingredients, like peptides.
  • It contains soy, which can be a common allergen.

Price: $530

Key Ingredients: Ursolic acid, Shiitake, Ginkgo Biloba, Tormentil, Ruscus, Phytosqualane, Sunflower, Glucolipids

La Prairie Skin Caviar Luxe Cream

This is a rich, luxurious, and expensive cream with high-class ingredients including caviar. It’s rich in antioxidants that repair, nourish, and protect the skin. It also deeply hydrates the skin, serving as an excellent moisturizer and restoring volume. This helps in turn with wrinkles and fine lines. This product, with the help of caviar and other ingredients, also improves the skin tone. You’ll be amazed by the anti-wrinkle cream before and after.

La Prairie Skin Caviar Luxe Cream

Pros

  • The product tightens the skin.
  • It can improve skin tone.
  • This cream deeply hydrates the skin.

Cons

  • This is a very expensive cream.
  • It’s not suitable for people who are allergic to seafood.

Price: $510

Key Ingredients: Swiss Caviar, Sodium Hyaluronate, Sage, Arginine, Algae Extract, Shea Butter, Panax Ginseng

Skin Medica Age Defense Retinol Complex

This is a very concentrated serum anti-wrinkle cream with retinol. This is a powerful antioxidant that repairs skin damage and protects it from harm by targeting dangerous free radicals. This product diminishes wrinkles, improves tone and texture, and contributes to skin’s resiliency.

Skin Medica Age Defense Retinol Complex

Pros

  • It’s suitable for all skin types, including sensitive.
  • It can diminish the appearance of lines.
  • The product renews and refreshes the skin.

Cons

  • It contains brand and soy, which are common allergens.
  • You could develop a skin reaction.
  • It may increase your sensitivity to the sun.

Price: $93

Key Ingredients: Retinol, Peptides, Niacinamide, Tocopherol, Magnolia Bark Extract, Soy Oil

Dr. Dennis Gross Skincare Ferulic + Retinol Anti-Aging Moisturizer

This anti-aging moisturizer contains retinol combined with ferulic acid and an ECG Complex to visibly improve your complexion. It helps to moisturize, repair the skin barrier, and smooth out wrinkles and lines. It can renew overall texture and make it smoother to the touch. It can also get rid of dark spots on the skin.

Dr. Dennis Gross Skincare Ferulic + Retinol Anti-Aging Moisturizer

Pros

  • This product helps firm the skin.
  • It can improve fine lines and wrinkles.
  • This serum can make the skin surface smoother.
  • Cons

    • It contains soy, which is a common allergen.
    • There are many ingredients, which increases the chances of having a skin reaction.

    Price: $75

    Key Ingredients: Retinol, Ferulic Acid, ECG Complex, Gallic Acid

    How to Get the Most Out of Your Anti-Aging Creams and Serums

    Here are a few tips which will help you get the best use of the anti-aging products you’re using:

    • Before you use a new product, do a patch test on a small area of skin, such as your inner forearm. If there is no reaction after 48 hours, you can safely use the cream.
    • Remember that it’s not the best idea to use more than one anti-aging product. This will make it more likely that you’ll have a skin reaction, and would make it difficult to know which product you are sensitive to (1).
    • Even if your wrinkles improve, you still need to continue to use the products to keep the desired results.
    • Be patient with these products. Sometimes it takes weeks or even a few months to see anti-aging results. Don’t give up.

    FAQ’s

    Q: At what age should you start introducing anti-ageing wrinkle creams to your skincare regimen?

    A: Although the visible signs of age like wrinkles and fine line may not appear until middle age, the skin actually begins to age when you’re in your 20s. That is when you begin to lose collagen so that your skin begins to sag. This is a good time to start adding anti-wrinkle cream to your routine, in order to prevent further damage and protect the skin from harm (2).

    Q: How do I use anti-aging face creams?

    A: With most of these anti-aging face creams, you take a small amount on your fingertips and gently rub across the areas you would like to focus on. Massage the skin until the product becomes completely absorbed. At that point, you can add other products on top like a moisturizer, sunblock, and makeup.

    Q: How often do I use them?

    A: You use most anti-aging creams either first thing after you wake in the morning and/or before you go to sleep, depending on the specific product.

    Q: What are the key ingredients one should look for in an anti-ageing product to fight wrinkles?

    A: Some of the most popular and effective ingredients included in anti-aging products are Vitamin C, Retinoids, Kojic Acid, Jojoba Oil, Caffeine, Peptides, Coenzyme Q10, Grape Seed Extract, Hydroxy Acids, Argireline, Squalane, Niacinamide, Tea Extracts, Hydroquinone, and Apricot Oil.

    Q: I use different formulas for my morning and night skincare regimen. Is this beneficial?

    A: You can absolutely use different products and different brands morning and night. Don’t switch around products too often or use too many different products, as this can heighten sensitivity and decrease effectiveness. Always include SPF in your AM routine.

    Q: Which treatments would you recommend addressing wrinkles and other signs of ageing?

    A: In addition to anti-wrinkle cream, there are several other possible recommended treatments for removing wrinkles. Make an appointment with your local board-certified dermatologist to discuss these further in-depth. Options include alternative prescription topicals and other treatments like botox, fillers, lasers, and chemical peels.

    Q: Do you have any dermatologist preferred anti-ageing wrinkle creams to recommend?

    A: What anti-wrinkle cream is the best? It’s hard to say, but here are some good ones:

    One excellent brand is Dermalogica Skin Smoothing Cream Moisturizer. The product provides the skin with 48 hours of hydration, gets rid of dry skin, and smooths out wrinkles and fine lines. It also has anti-inflammatory benefits and is very soothing for the skin. This is an anti-wrinkle cream that works.

    Another fantastic anti-wrinkle cream is Drunk Elephant A-Passioni Retinol Cream. It contains some incredibly nutritious superfoods, as well as retinol and some very hydrating ingredients. This effective anti-wrinkle formula is highly recommended.

    In addition, consider looking into some wrinkle cream under the eyes and wrinkle cream neck.

    Q: Are there any problems with using these products if you don’t have sensitive skin?

    A: As with any topical product, there is a small chance you may end up with a skin reaction, perhaps due to an allergy to one of the ingredients. This would involve a rash, facial redness, or perhaps small bumps. If this occurs, you should not continue using the product. You can test first on your arm as previously mentioned.

    Q: Do anti-aging products really work?

    A: There are some very potent anti-aging ingredients in existence that are backed by research, some of which we have mentioned in this article. These may be more effective for certain patients than others. It is okay to try a few different ones until you find which is right for you.

    Q: When should you use anti-aging products?

    A: It’s best to use an anti-wrinkle product first thing in the morning and before you go to bed, depending on the specific product.

    Is there anything else we should know about taking care of our skin?

    There are a number of natural things you can do to enrich your skin and slow down aging. For example, eating a healthy diet rich in nutrients, vitamins, minerals, and antioxidants will help keep the skin healthy and elevate immunity. In addition, exercising regularly will improve circulation to the skin, which helps to maintain its function and appearance.

    Drinking water is very important to hydrate the skin, and it can help combat signs of aging. Also, stay out of the sun and wear sunblock when you are outside (at least SPF 30 or higher). UV rays are very detrimental to the skin and will speed up aging.

    Finally, follow a strict skin care routine every morning and every night with cleansing, toning, moisturizer, SPF and find an anti-wrinkle cream that really works.

Dermspotlight Beauty

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Joanna McGetrick, MD, FAAD

By Joanna McGetrick, MD, FAAD

Dr. Joanna McGetrick, MD is a Dermatologist in Orlando, Florida. She is board certified by the American Board of Dermatology. She focuses on a combination of complex medical dermatology, surgical procedures, and cosmetic dermatology.