What is DefenAge?

DefenAge is an American skincare brand designed to manufacture clean-beauty, anti-aging skincare products for all skin types.

The company uses innovative processes and quality ingredients to make its products. The products are vegan-friendly and are free of human or animal ingredients.

Fast Facts

DefenAge Skincare

Brand Background: DefenAge skincare was founded in 2014 by a group of medicine experts.
Best for: DefenAge skincare products are best for individuals who want to fight aging. The products tackle aging skin, dull skin, wrinkles, dark spots, and dark circles.
Key Ingredients: Age repair defensins, niacinamide, hyaluronic acid, sea whip, fine blends of natural antioxidants, glycerin, phospholipids, vitamin E, squalene, panthenol
Price Range: DefenAge products range between $80 to $300
DefenAge Skincare
DefenAge Skincare. Image/Dermspotlight

How Does It Work?

DefenAge manufactures its products using clean beauty and quality ingredients. Each ingredient has been tested to ensure it is safe for the skin.

The products contain age-repair defensins, hyaluronic acid, niacinamide, sea whip, and polyphenols that help improve skin appearance.

The products also help reduce the appearance of wrinkles, fade discoloration, brighten skin tone, and improve skin texture.


*All individuals are unique. Your results can and will vary.

What Are the Best-Selling DefenAge Products?

DefenAge 8-in-1 BioSerum

The 8-in-one smart formula helps reduce the appearance of wrinkles, fade hyperpigmentation and discolorations, improve skin elasticity, promote skin radiance, and improve skin appearance.

The BioSerum contains age-repair defensins that promote the synthesis and regeneration of new skin cells.

DefenAge 8-in-1 serum ingredients include niacinamide, hyaluronic acid, and sea whip that help even out skin tone, keep the skin hydrated, and protect the skin against damage by free radicals.

Bottom line: DefenAge 8-in-1 BioSerum contains age-repair defensins, niacinamide, hyaluronic acid, and sea whip that helps improve skin elasticity, reduce the appearance of wrinkles, improve skin texture, and brighten the skin complexion.

DefenAge Clinical Power Trio

The Clinical Power Trio contains 8-in-1 BioSerum, 24/7 Barrier Balance Cream, and 2-Minute Reveal Masque all in their full sizes.

The skincare treatment helps correct any signs of skin exhaustion and reduces the signs of aging in as little as six weeks.


*All individuals are unique. Your results can and will vary.

The directions for using the trio kit are available online and should be followed for the best results. The products contain clinically studied ingredients that help improve skin appearance and support healthy-looking skin.

Bottom line: DefenAge Clinical Power Trio fragrance free contains three products with powerful ingredients that help fight age, smoothen skin texture, even out skin tone, keep the skin hydrated, and brighten skin complexion.

DefenAge 3d Eye Radiance Cream

The anti-aging skincare formula tackles the skin around the eye. The age-repair defensins in the product help firm, lift, and smooth the upper eyelids, fade dark circles, reduce puffiness, and reduce fine lines around the eyes.

You can safely apply the formula under the eyes and on the upper eyelid. Eye Radiance Cream can be used as a standalone eye product or combined with retinol.

DefenAge Eye Cream contains hyaluronic acid to help hydrate the skin around the eyes and improve skin texture.

Bottom line: DefenAge 3d Eye Radiance Cream is formulated with age-repair defensins and hyaluronic acid to help take care of the skin around the eye area.

DefenAge 24-hour Fast Starter Kit

The 24-Hour Fast Starter Kit is a trial version of the brand’s Clinical Power Trio. The skincare regimen includes a 2-3-day supply of 8-in-1 BioSerum, 24/7 Barrier Balance Cream, and 2-Minute Reveal Masque. You can use the kit during the weekend and see a brighter complexion in a few days.

Bottom line: DefenAge 24-Hour Fast Starter Kit contains defensins, niacinamide, hyaluronic acid, and sea whip to help promote production of new cells, protect the skin’s moisture barrier, soothe and calm the skin, and improve skin elasticity.

DefenAge 6-week perfection Neck Tightening Cream

The neck tightening cream helps reduce the appearance of gravitational wrinkles around the neck. It also helps tighten and lift neck skin, improve skin thickness, and moisturize the skin.

According to the manufacturer, you can start seeing noticeable results after two weeks of application. The formula can be used at early or late stages of neck aging.


*All individuals are unique. Your results can and will vary.

DefenAge cream contains natural extracts, fine blends of peptides, niacinamide, and other molecules that help activate new skin cells.

Bottom line: DefenAge 6-week Perfection Neck Tightening Cream contains powerful ingredients that help reduce wrinkles, improve skin firmness, and hydrate the neck skin making it more youthful.

What Are the Ingredients in DefenAge?


Peptides or polypeptides are amino acids that help build skin proteins, including collagen. More collagen in the skin helps improve skin elasticity, reduce fine lines and wrinkles, plump up the skin, and promote the synthesis of new skin cells.

Peptides also help calm skin inflammation, repair damaged skin, and clear breakouts. A publication in the International Journal of Molecular Sciences claims that topical application of peptides improves the appearance of wrinkles on the skin.


Niacinamide is a form of vitamin B3, and it provides numerous benefits to the skin. Research supports that niacinamide helps build keratin and protect the skin’s lipid barrier. Niacin also helps regulate sebum production, minimize the size of pores, fade hyperpigmentation, and prevent photodamage as mentioned in our Drmtlgy Needle-less Serum Reviews article.

According to the National Library of Medicine, some concentrations of niacinamide also help fight acne and reduce the appearance of wrinkles and fine lines.

Age-repair defensins

Age-repair defensins are a retinol alternative that help promote regeneration of new skin cells. DefenAge creams and DefenAge serums contain age-repair defensins. These natural molecules stimulate production of new cells in the body to promote youthful-looking skin.

According to DefenAge clinical studies, age-repair defensins are key performance ingredients in their skincare products that help fight age by reducing the appearance of wrinkles.

Sea whip

Sea whip extract is derived from gorgorian coral. It is a powerful anti-inflammatory ingredient included in some skincare products. Sea whip helps reduce skin redness, calm inflammation, reduce swelling, soothe irritated skin, and rosacea.

The Journal of Cosmetic Dermatology reveals that sea whip extract soothes inflamed and irritated skin.

SEE ALSOAngelLift Reviews – Do AngelLift Dermastrips Really Work As Advertised?

Pros and Cons of DefenAge Skincare


  1. DefenAge skincare products contain age-repair defensins that help reduce the appearance of wrinkle
  2. The brand products help improve skin firmness and elasticity
  3. DefenAge fly kit is TSA-friendly
  4. DefenAge reviews are available online


  1. You can only make your purchases through the official website
  2. DefenAge products are relatively expensive compared to other skincare products
  3. The combination of some products may need more research
  4. May not work exactly the same for everyone

What is the Return Policy for DefenAge?

If the product does not meet your requirements, you can contact customer care and return the product. DefenAge New skin offers a 30-day money-back guarantee on all its products.

How Does DefenAge Rate?

Feature Rating Comments
Safety 10/10 The manufacturer claims that they use clean-beauty and quality ingredients that do not contain any toxins. The products are safe for skincare.
Performance 8/10 DefenAge results can be seen in as early as six weeks of use. You can checkout DefenAge before and after photos and see how people have experienced results.
Average customer ratings 5/5 stars Most people have given the product a rating of 5 out of 5 stars.

DefenAge FAQ

Q: How Are the Reviews for DefenAge?

A: DefenAge skincare reviews are generally positive and are from real customers. According to DefenAge clinical power trio reviews, customers are happy with the product results and would recommend it to others. DefenAge 3d eye radiance cream reviews and DefenAge 8 in 1 BioSerum reviews prove that the products do not disappoint.

Q: Is DefenAge a Medical Grade Skin Care Line?

A: Yes, DefenAge is a medical-grade skincare brand

Q: Is DefenAge Safe?

A: DefenAge products are safe for the skin since the ingredients have undergone rigorous clinical tests

Q: How Should You Use DefenAge?

A: The directions for using each product are available on the official website

Q: Who Manufacturers DefenAge?

A: DefenAge is the company that manufactures these premium-grade skincare products

Q: Are DefenAge Products Safe During Pregnancy?

A: Pregnant mothers should consult their dermatologists before they add any product to their skincare regimen.

DefenAge Alternatives

Brand Cost Range Key Ingredients
Dermelect $7-$78 Argireline, Collagen, Keratin Peptides, Glycolic Acid, Hyaluronic Acid, Salicylic Acid, L-Ascorbic Acid
Serious Skincare Approx. $10-$60 Glycolic Acid, Aloe Vera, Royal Jelly, Sunflower Seed Oil
TULA Skincare $24.00 – $168.00 Probiotic extracts, prebiotics, Salicylic acid, Niacinamide, Azelaic acid, Willow herb, Hyaluronic acid, peptides, squalane, grape seed oil, vitamin C
Youn Beauty $19.99 – $367.00 Concentrated retinol, Vitamin C, Hyaluronic acid, and Kojic acid


DefenAge skincare line manufacturers many skincare products, and it also includes DefenAge men’s kit, DefenAge skincare clinical power trio, and DefenAge all in one kit.

The company claims that they use quality and safe ingredients that provide optimum results. The products help address various skincare concerns. Consult your dermatologist and find the product that is best for your skin.

Up NEXTApril Skin Reviews – Do April Skin Care Products Work & Safe To Use?

4 sources

[1] Anti-Wrinkle Benefits of Peptides Complex Stimulating Skin Basement Membrane Proteins Expression: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981886/
[2] Nicotinic acid/niacinamide and the skin: https://pubmed.ncbi.nlm.nih.gov/17147561/
[3] Age-repair defensins: https://defenage.com/6-week-perfection-neck-tightening-cream.html?size_option=1-5-fl-oz-45ml-full-size&fragrance_option=fragrance-free
[4] A pilot study evaluating the efficacy and tolerability of a comprehensive, hydrating topical antioxidant developed specifically for men: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457217/