Skincare Ingredients Glossary

Argireline for Skin: What Is It, How It Works, Do You Need It (The Complete Guide)

Dermatologists say Argireline is the closest thing to Botox you can get. But, is it safe to use long term on your skin? Does Argireline Work? Let's find out here!
By Dermspotlight Staff,
Updated November 19, 2020

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What is Argireline Peptide?

Argireline is a chain of amino acid peptides which has potent anti-aging properties. It’s also referred to as Acetyl Hexapeptide-8. This is a synthetic peptide which is the basis for the production of collagen and elastin. It’s very similar to Botox and performs similar functions. For example, it’s very effective at smoothing out wrinkles and expression lines on the skin, and research has confirmed this positive effect. (1)

The Argireline benefits for skin are extensive. This substance is good for people who want to get rid of the signs of aging, and it’s also effective in treating dry skin. Argireline peptide provides some moisturizing benefits. In fact, it’s sometimes combined with hyaluronic acid to add to the hydration provided to the sensitive skin.

Argireline: How Does it Work?

Argireline inhibits the release of the brain neurotransmitter acetylcholine, and this lessens the contractions in the muscles of your face. This makes it appear as if you have less visible wrinkles and frown lines.

Unlike Botox, this peptide is perfectly safe. Unfortunately, it doesn’t permeate very well into the skin, so it’s often combined with another ingredient or a peptide like tripeptide-10-cirtrulline to enhance this ability. (1)

Argireline peptide also induces the production of additional collagen in the body. Collagen exists naturally in the skin, but it diminishes with time. As a result, this can lead to wrinkles and sagging skin. (2)

The additional collagen makes the skin firmer and more elastic, and this helps to smooth out under eye wrinkles and fine lines. However, it can also enhance the hydration of the skin, which moisturizes and gives you a more youthful appearance.

Argireline: How to Use

Argireline skin care products usually comes in the form of a cream or argireline serum. There will be very specific instructions on the product itself to follow. We recommend Argireline solution 10% as a very enriching product.

Generally, you want to cleanse your face and dry with a towel before you begin the application. Take a small amount of the product onto your fingers and rub it in the specific areas that you want to target. Rub the cream or serum in until it’s absorbed properly.

Many experts say anti-aging creams with argireline like Advanced Dermatology, Image Skin Care, Jeunesse, or serums, are the best non-injection treatment for fighting wrinkles and other signs of age on the face.

Where to Buy Argireline Cream

You can purchase argireline face cream, argireline eye cream, and argireline serum from a number of online and offline retailers because it’s very widely distributed and easy to find. There are products which include mostly argireline for skin, and others that have additional skin care and anti-aging ingredients.

Pay close attention to the other substances included, as they will enhance the effects of the peptide and provide you with additional benefits. If you have dry skin, for example, look for a product like La Mer Cream, Instantly Ageless, and Clinique with extra hydrating ingredients.

What Does Argireline Do for Skin?

Argireline in skin care makes the skin much firmer, gets rid of the signs of aging like wrinkles and fine lines, hydrates the skin deeply, dark circles under the eyes, and eliminates dryness. It basically slows down the movement of the muscles in your face in a similar way to Botox, and this makes your skin appear smooth and youthful-looking. Additionally, it also replaces lost collagen in the skin.

Can Argireline Damage Skin?

Argireline for skin has no toxicity at all associated with it, unlike Botox. In addition, it’s a substance which apparently has no side effects associated with it at all. It will not damage your skin, in fact, it will only provide enrichment. It can actually repair some of the harm done.

What is Argireline Solution?

This is a water-based liquid product which you’re meant to apply directly on your skin. It only requires a few small drops to absorb into your skin and has an anti-aging effect. This product will eliminate wrinkles and expression lines on your face. One Argireline review highly recommended the Argireline solution 10% as an effective product.

Where Does Argireline Come From?

Argireline is a synthetic peptide which comes from acetyl hexapeptide-3, a peptide which is closely related to Botox. However, it’s made to be much safer than Botox with few side effects or negative consequences.

People Also Ask

Q: Can You Use Argireline With Vitamin C?

A: Some manufacturers warn that you shouldn’t use argireline peptide with pure Vitamin C. However, generally speaking, this is a great skin care combination. Vitamin C is high in antioxidants, which repair damage to the skin, facial redness, and assist in getting rid of wrinkles and lines.

It also kills damaging free radicals on the skin and lowers oxidative stress, which helps to preserve the collagen and elastin. These two ingredients create an anti-aging powerhouse which would be very effective in anti-aging products such as No. 7 Serum, Meaningful Beauty, The Ordinary, and Plexaderm.

ALSO READVitamin E for Skin

Q: Can You Use Argireline With Retinol?

A: Beauty experts recommend that you do not use retinoids and peptides together at the same time. You can use them both, just alternate days. The reason behind this is not very clear, but it’s likely because they are both just too potent to use together.

Q: Can I Use Argireline With Hyaluronic Acid?

A: You certainly can, and in fact, these two very beneficial anti-aging substances are often found together in skin care products like Perricone MD, Mario Badescu Skin Care, Nu Skin, and Arbonne. The hyaluronic acid boosts the level of hydration provided by the peptide, which helps to give the skin volume and smooth out wrinkles and expression lines. It also moisturizes the skin, leaving it soft and smooth.

Q: Can I Use Argireline With Niacinamide?

A: Niacinamide has numerous benefits for the skin, including softening wrinkles and expression lines, evening out skin tone, shrinking pore size, and strengthening the surface of the skin. This substance is unusual in that it can go alongside any other ingredient. In addition, it’s a very gentle ingredient and is an excellent accompaniment to argireline in an anti-aging product.

Which is better, Argireline, or Matrixyl?

They are both very effective peptides, but they work differently. Matrixyl is composed of 2 peptides which mimic the behavior of damaged collagen. When the skin notes that there is a problem with the collagen, it immediately begins to make more to replace it. This additional collagen can firm up the skin, smoothing out wrinkles and fine lines.

Argireline peptide slows down contractions in the face muscles, making the skin appear as if it has less lines and wrinkles. It’s very similar to Botox. Both of these substances will deliver potent anti-aging effects, it’s a matter of preference which one you would rather use.


Are you looking for an anti-aging ingredient that will give you that Botox-like effect, without the actual Botox itself? Do you want to eliminate those under eye bags, wrinkles and fine lines for good? It could be the substance that you’re looking for. It has a very similar effect and behavior to Botox, without the associated side effects or risks. The Argireline benefits for skin are plentiful.

This synthetic peptide can slow down the movement of the muscles in your face, giving the appearance of less wrinkles and expression lines. It also creates the production of collagen, which firms the skin and makes it more elastic. This also helps to get rid of forehead wrinkles and crow’s feet. In addition, it provides the skin with moisture.

Argireline is an anti-aging peptide which has some powerful effects on the skin. You can buy it in the form of an argireline serum, argireline cream, or argireline peptide solution from numerous beauty companies such as Rodan + Fields, Proactiv, Murad, Mary Kay, and Obagi online and offline. You can combine it with other ingredients to enhance its effects. If you want a potent anti-aging substance to eliminate your wrinkles and lines, this one is a good choice.

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Sheila Barbarino, MD, FAAO, FAACS, F.A.C.S.

By Sheila Barbarino, MD, FAAO, FAACS, F.A.C.S.

Sheila Barbarino, MD, FAAO, FAACS, FACS., a board-certified surgeon with a fellowship in oculofacial plastics/cosmetic plastic surgery, specializes in full-body cosmetic surgery.